Membrane lipids S2M2
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Membrane lipids S2M2
What are the four major phospholipids
All phospholipids contain
Cardiolipin is important for what membrane
What is the only glycerophospholipid that is antigenic
Dipalmitoylphosphatidylcholine is a major component of
What is found in snake and bee venom that makes them especially toxic
Phospholipase A2 is important for the synthesis of
Phospholipase A2 is found to be in high amounts of what secretions
What inhibits Phospholipase
Platelet activating factor (PAF) is released from phagocytic cells and has what effect
Causes platelets to aggregate
Causes anaphylactic responses
Causes macrophages to produce super oxide radicals
Phosphatidylethanolamine is found to be abundant in what tissue
Phosphatidylcholine is found to be abundant in what tissue
Plasmalogen deficiency plays an important role in
What phospholipid is abundant in myelin sheaths
What determines blood groups
"The Gangli guys are always the ones making decisions"
What is the enzyme deficient in Tay-Sachs disease
What is a classic clinical finding in Tay-Sachs disease
Cherry red macula
What accumulates in Tay-Sachs
What are the symptoms for Gaucher disease
"Auch!!, mental retardation, osteoporosis, and a big spleen!"
What is deficient and accumulating in Gaucher disease
What are symptoms of Fabry disease
Reddish purple skin rashes
"It ain't no fable, her skin is as red as a stable"
What is deficient and accumulating in Fabry disease
affecting patients "sides" with skin rashes
Neimann Pick disease has what symptoms
"Don't pick retardation or hepatosplenomegaly"
What is deficient and accumulating in Neimann Picks disease
"Neimann marcus makes you sphing"
What are the symptoms of Krabbes disease
"Krabbs are blind, deaf and deteriorated"
What is deficient and accumulating in Krabbes disease
"Krabbs want to go to the galactic empire"
Sandhoff disease has what symptoms
Same as Tay Sachs but with visceral involvement
What is deficient and accumulating in Sandhoffs disease
What is the rate limiting step for cholesterol synthesis
"OMG, did you just stop cholesterol synthesis!?"
What is the rate limiting step of Bile acid synthesis
7 alpha-hydroxylase requires what for activation
Thyroid hormones and Vit C
What are the secondary bile acids
What is the only possible mechanism for excretion of excess cholesterol in the feces
What are some symptoms of an obstructed bile duct