DOPAMINE (Dopamine hydrochloride, Intropin)

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Author:
Kylecon40
ID:
93412
Filename:
DOPAMINE (Dopamine hydrochloride, Intropin)
Updated:
2011-07-08 16:11:50
Tags:
DOPAMINE Dopamine hydrochloride Intropin
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DOPAMINE (Dopamine hydrochloride, Intropin)
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  1. Class
    Sympathomimetic (both Alpha and Beta properties)
  2. Trade name
    Intropin®
  3. Description
    Naturally occurring neurotransmitter and precursor to norepinephrine.
  4. Actions
    • • At low and medium doses, selectively dilates blood vessels supplying the brain, kidneys, heart and gastrointestinal tract.
    • • At medium to high doses, increases cardiac output by increasing contractility and stroke volume, thereby increasing blood pressure.
    • • At high doses, causes vasoconstriction and increased heart rate.
    • • Stimulation of alpha and beta-receptors
  5. Indications
    • To increase end-organ perfusion in:
    • 1. Cardiogenic shock
    • 2. Significant hypotension not caused by hypovolemia.
  6. Contraindications
    Hypovolemia
  7. Side Effects
    • Largely dose dependent
    • 1. Tachycardia, ectopy, arrhythmias
    • 2. Palpitations, chest pain
    • 3. Tissue necrosis from extravasation
    • 4. Gangrene from peripheral vasoconstriction
    • 5. Nausea/Vomiting
  8. Administration
    • 400 mg in 250 mL D5W (1600 μg/mL)
    • Renal: 2-5 μg/kg/min
    • Cardiac (Inotropic): 5-10 μg/kg/min
    • Vasopressor: 10-20 μg/kg/min
  9. Onset/duration
    <5 min, duration less then 10 min after discontinuation

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