Describe how each of the following inhibits protein synthesis: aminoglycosides, tetracyclines, chloramphenicol, macrolides.
aminoglycosides-by changing the shape of the 30S portion of the 70S prokaryotic ribosome. This interference causes the genetic code of the mRNA to be read incorrectly
tetracyclines-interferes with the attachment of the tRNA carrying the amino acids to the ribosomes at the 30S portion of the 70S ribosome, preventing the addition of amino acids to the growing polypeptide chain
chloramphenicol-inhibits the formation of peptide bonds in the growing polypeptide chain by reacting with the 50S portion of the 70S prokaryotic ribosome. Because of its simple structure, it is less expensive for the pharmaceutical industry to synthesize it chemically than to isolate it from Streptomyces
macrolides-by blocking the tunnel