shosh: DNA viruses

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shosh: DNA viruses
2011-07-13 10:50:41

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  1. Six DNA viruses
    • Adenovirus
    • Hepadnavirus
    • Herpesvirus
    • Papovavirus
    • Parvovirus
    • Poxvirus
  2. Enveloped DNA viruses
    • Herpesvirus
    • Hepadnavirus
    • Poxvirus
  3. Naked DNA viruses
    • Adenovirus
    • Parvovirus
    • Papovavirus
  4. Non-enveloped RNA viruses
    • Reovirus--dsRNA
    • Calicivirus--sense RNA
    • Picorna--sense RNA
  5. Enveloped non-icosahedral DNA virus
  6. Function of hemagglutinins
    Promote attachment of virus to host cell
  7. Function of neuraminidase
    Hydrolyzes sialic acid, helps release virions from host cells
  8. Live attenuated vaccines
    Smallpox, yellow fever, chickenpox, Sabin's polio vaccine, MMR (only live vaccine that can be given to HIV patients)
  9. Killed vaccines
    Rabies, influenza, Salk's polio vaccine, HAV
  10. Only ssDNA virus
  11. Site of replication for DNA viruses
    All DNA viruses replicate in the nucleus, except for poxvirus, which replicates in the cytoplasm
  12. Origin of herpesvirus envelope
    Host cell nucleus
  13. Adenovirus
    • Naked, linear dsDNA virus
    • Causes febrile pharyngitis (sore throat), conjunctivitis, and pneumonia
    • Live, non-attenuated oral vaccine given to military recruits
  14. Papovavirus (name two clinically relevant ones)
    • Naked, circular dsDNA
    • HPV causes warts and cervical cancer
    • JC virus causes PMLE in IC patients
  15. HSV
    • Enveloped, linear dsDNA
    • Oral and genital lesions, keratoconjunctivitis
    • Causes vesicular lesions in the distribution of an infected dermatome
    • Diagnose by identification of multinucleated giant cells on Tzanck smear
    • Treat with acyclovir
  16. Varicella zoster
    • Enveloped, linear dsDNA
    • Causes chickenpox and shingles
  17. Epstein-Barr
    • Enveloped, linear dsDNA
    • Causes infectious mono
    • Replicates first in epithelial cells, then in B lymphocytes
    • Positive agglutination test with heterophile antibodies
    • Associated with Burkitt's (8:14 translocation) and nasopharyngeal carcinoma
  18. Atypical lymphocytes indicate...
    EBV infection-->mono
  19. CMV
    • Enveloped, linear dsDNA
    • Mono in immunocompetent patients
    • Pneumonia, hepatitis, GI ulcerations, and CMV retinitis in immunocompromised patients
  20. Infection that causes neonatal periventricular calcification, deafness, and hemorrhagic cutaneous lesions
  21. First choice treatment for CMV in immunocompromised patients
  22. Way to distinguish between EBV mono and CMV mono
    Monospot test with heterophile antibodies is positive in EBV infection and negative in CMV infection
  23. Parvovirus b19
    • Naked linear ssDNA
    • Causes aplastic crisis in sickle cell patients, slapped cheek fever, and hydrops fetalis