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It is used to reverse the sedative effect of benzodiazepines
Mechanism of Action
Flumazenil antagonizes the actions of benzodiazepines in the CNS. Inhibits their action on the gamma aminobutyric acid- benzodiazepine complex. Reverse the sedative effects of the benzodiazepine.
Onset of Action
Half Life:54 min
To reverse CNS and respiratory depression associated with benzodiazepines
Know hypersensitivity to drug
Administer with caution to PT’s dependant on benzodiazepines because it may induce life-threatening benzodiazepine withdrawal, do not use as a “coma cocktail”
0.2 mg IV over 30 seconds, repeated as needed to a max dose of 1.0mg
Routes of Administration