Effects of Short-Term Use – Higher Doses - Morphine
Intensification of morphine’s low-dose effects may occur with administration of higher doses. Duration of effects also increases with increased dosage. As the dose increases, sensitivity and emotionalresponse to painful stimuli decrease, probability of sleep increases, ability to concentrate is increasinglyimpaired, breathing becomes progressively slower and more shallow, heart rate gradually slows andblood pressure decreases. The rush also increases in intensity. In very high doses, the CNS depressioncan be profound resulting in coma. The heart rate is irregular and respiration is shallow. The bodytemperature is low. The skin is cold and clammy, and the pupils are constricted.