Breast Cancer Path

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Author:
bigfootedbertha
ID:
94328
Filename:
Breast Cancer Path
Updated:
2011-07-17 17:35:07
Tags:
breast cancer pathology
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Description:
for path exam
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  1. Which cancers are bilateral and multifocal?
    • Cysts and fibrosis
    • lobular carcioma in situ
  2. Which cancers are b/l?
    Infiltrating lobular cancer of the breast
  3. Which cancers have a poor prognosis?
    • Those with a high proliferation rate
    • Overexprssion of HER2/NEU
    • Angiogenesis (increased likelihood of METS)
    • Multiple intraductal papillomas likely to become malignant
    • Infiltrating lobular carcinoma of the breast
  4. Prominent lymphocytic infiltrate
    Medullary carcinoma of the breast
  5. Inflmmatory component
    Inflammatory cancer (rapidly spreading tumor)
  6. Bull's eye apperance
  7. infiltrating lobular cancer
  8. An absence of ERs and PRs affects tx how?
    less responsive to hormonal therapy, but more responsive to chemo
  9. Which type of fibrous masses are more likely to progress to cancer?
    • Fibrocystic changes: benign to increased risk of carcinoma
    • Fibroadenomas RARELY malignant
  10. Which masses have a minimal or no increased risk for cancer?
    fibrosis, mild hyperplasia, ductal papillomatosis
  11. Which masses have a slightly increased risk for cancer?
    moderate to florid hyperplasia, ductal papillomatosis,
  12. Which masses have a significantly increased risk for cancer?
    atypical hyperplasia
  13. Where is breast cancer most likely to spread?
    • the IPSILATERAL LN first
    • Bones, lungs, liver
    • may invade perineural, perivascular spaces and BVs
  14. Tumoer adherent to muscles or deep fascia
    fixation
  15. rapid spreading tumor causing an acute inflammatory reaction
    inflammatory cancer
  16. When is microcalcification common and uncommon?
    infrequent in intraductal cancer, more common in infiltrating cancer
  17. Which breast tends to be affected more?
    left
  18. Most breast cancers arise in what part of the breast?
    upper outer quadrant in the ductal epithelium
  19. nipple retraction, skin dimpling (tugging on cooper's ligaments)
    IDC
  20. Bleeding, whitish discharge and ulceration of the nipple
    Paget's disease
  21. Fissured and ulcerated, oozing areola and nipple
    Paget's disease
  22. Hyperchromatic cells with pleomorphic nuclei surrounded by a halo
    Paget's disease
  23. What determines the prognosis of Paget's disease?
    extent of ductal cancer
  24. Palpable lumps that can vary during menstrual cycles
    fibrocystic changes
  25. Blue dome cysts containing turbid fluid
    cysts and fibrosis
  26. Cysts lined by cells with granular pinkish eosinophilia
    Apocrine metaplasia, associated with cysts and fibrosis
  27. Proliferation of cells with a duct NOT producing a clinically discrete masses
    epithelial hyperplasia
  28. hard rubbery consistency
    sclerosis adenosis
  29. Masses of small gland patterns with firbous stroma
    sclerosing adenosis
  30. Discrete palpable, encapsulated, freely moveable with tan/white color
    fibroadenoma
  31. Leaf like, may be massive in size
    Phyllodes tumor
  32. Papillary growth withi a duct leading to bloody nipple discharge
    intraductal papilloma
  33. anaplastic cells that are proliferating within the DUCT, but do not permeate the BM
    Intraductal carcinoma
  34. difficult if not impossible to palpate
    lobular carcinoma in situ
  35. 3-4 cm stony hard consistency
    invasive ductal carcinoma
  36. Typical intraductal cancer that extends to and infiltrates the skin of the nipple and areola
    Paget's disease
  37. Large, soft, and fleshy
    Medullary carcinoma of the breast
  38. Soft, bulky, gray-blue mass
    Colloid (mucinous) carcinoma
  39. Poorly circumscribed, rubbery, difficult to palpate
    infiltrating lobular cancer of the breast
  40. Most common benign tumor of the breast
    fibroadenoma
  41. Age range affected by fibroadenomas
    3rd decade
  42. Fibroblastic stroma with duct like spaces
    fibroadenoma
  43. subareolar tumor
    intraductal papilloma
  44. rare to have nipple retraction
    intraductal papilloma
  45. necrotic tumor tissue in the middle of ducts
    comedocarcinoma, associated with intraductal carcinoma
  46. Most common form of breast cancer
    invasive ductal carcinoma
  47. Dense fibrous stroma (desmoplasia) with nests or cords of tumor cells that can cause nipple retraction and skin dimpling
    invasive ductal carcinoma
  48. Large cells not forming sheet like infiltration and lymphocytic infiltration
    Medullary carcinoma of the breast
  49. Strands of tumor cells one cell in width (Indian filing)
    Infiltrating lobular cancer of the breast
  50. Most common type of alteration in the breast
    non-proliferative change
  51. Clinical and morphologic features similar to a carcinoma
    sclerosis adenosis
  52. Benign and cured by excision
    phyllodes tumor
  53. starburst appearance
    intrdcutal carcinoma
  54. size of mass indicating a favorable prognosis
    <2 cm, although they often aren't palpated until 3 or 4 cm
  55. Survival rate based on LN involvement
    • None: 80% 5 year survival
    • >4: 21% five year survival
  56. Affect of proliferative rate on tx
    Poorer prognosis but respond better to chemo
  57. may invade perineural, perviascular spaces and blood vessels
    invasive ductal carcinoma

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