2nd line meds to be added to metformin.
Glyburide: oldest one. Cheap, but causes bad hypoglycemia, so not used a lot anymore.
Glipizide: better choice. Generic, so good for most pts.
Glimeperide: best choice, but not generic $$$.
MOA: Stimulate insulin secretion from pancreas.
Dosing: once daily, QAM
Therapeutic effectiveness wanes with time. Not very effective as monotherapy, but work well with metformin.
SE: Wt gain, hypoglycemic episodes