unit5/6 Pharmacology

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  1. What are the 3 differences between drug actions on CNS and ANS
    • 1. CNS includes inhibitory neurotransmitters
    • 2. Blood brain Barrier is involved
    • 3. Hyperpolarization
  2. What are the 2 neurotransmitter classifications in the CNS
    • 1. Excitatory
    • 2. Inhibitory
  3. Name the 5 Excitatory neurotransmitters in the CNS?
    • 1. Epinephrine
    • 2. Noraepinephrine
    • 3. Achetylcholine
    • 4. Glutamate
    • 5. 5-HT
  4. Name the 2 inhibitory Neurotransmittersin the CNS?
    • 1. DA
    • 2. Gaba
  5. What is a Seizure?
    A small population of neurons that goes through this rhythmic synchronous firing that causes a transient alteration in behaviour. Think of arrhythia of the brain.
  6. What is a convulsion?
    the jerkings and the spasms. (Commonly confused with seizures)
  7. What causes seizures?
    • 1. Hyperexcitability of neurons
    • 2. Mechanical
    • 3. Sudden drug withdrawal
    • 4. Toxins
    • 5. Heredity
    • 6. Idiopathic
  8. What are Partial seizures?
    siezures that happen only at the location where the bad nuerons exist. This is where most seizures happen
  9. What are generalized seizures?
    When bad neurons recruit other neurons during a seizure and convulsions usually proceed.
  10. What are the signs of partial seizures?
    1. No loss of consciousness, just tingling or numbing
  11. What are the signs of generalized seizures?
    • Tonic/Clonic (muscle control & jerking)
    • Absence (Freezing up)
    • Myoclonic (Brief Shock like)
    • Feveral (temp changes)
    • Status (never ending)
  12. What are the approaches to Treatment of Seizures?
    • 1. Control/Reduce Frequency
    • 2. Consider toxicity
    • 3. Seizure type determines drug
    • 4. Monotherapy
    • 5. Polytherapy
    • 6. Doses are Titrated
    • 7. Don't switch brands
  13. What are the common side effects for seizures?
    dizzines, lethargy/fatigue, drowsiness/sedation, ataxia. (Basically slows our brain down)
  14. What drug causes hyperactivity in children?
  15. What drug causes serious blood dyscrasias
    Carbamazepine (Tegretol)
  16. What drug causes Gingival hyperplasia?
    Phenytoin (Dilantin)
  17. What drug causes alopecia?
    Valproic Acid (Depakene, Depakote)
  18. What drug causes Steven Johnsons sickness?
    Ethosuximide (Zarontin)
  19. Which drug inhibits glutamate release?
    Lamotrigine (Lamictal)
  20. What is Parkinsons Disease?
    A neurodegenerative disorder that happens at the basal ganglia
  21. What is basal ganglia responsible for?
    smoothing out muscle movements
  22. What are the 2 neurotransmitters at work with Basal ganglia-Parkinsons?
    Dopaminne & Ach
  23. Explain the balance of Dopamin and ACH in Parkinsons's?
    Dopamine levels slowly decrease and this improper balance affects motion
  24. What is the basic approach to treatment of Parkinsons?
    Restore balance to Dopamine and ACH
  25. What are the basic symptoms of Parkinsons?
    • Resting Tremor
    • Cogwheel Rigidity
    • Difficulty swallowing
    • Bradykinisia
Card Set:
unit5/6 Pharmacology
2011-07-25 02:37:40
Santan ACC Pharmacology summer

Unit 5&6 Test cards
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