Card Set Information
Cerebral palsy is a ________ disorder?
Inability to perform rapid alternating movement is?
Dysdiadokokinesia - HD
The lower part of the ascending reticular activating system controls?
Lower motor neuron involvement results in?
Hypotonia, hyporeflexia, fasciculations
What disease has dance like movements?
What disease has blurry vision?
What disease has cogwheel rigidity?
What disease has fibrillary tangles?
What disease has loss of balance reactions?
What disease has involvement of the diaphragm?
What disease has muscle atrophy?
What disease has torticollis?
What disease has slow movement?
What disease has trouble initiating movement?
What disease has senile plaque?
What disease has spongiform encephalopathy?
What disease has progressive bulbar palsy and pseudobulbar palsy?
What disease has festinating gait?
What disease has prion as the culprit?
What disease has the agonist and antagonist muscle contracting simultaneously?
What disease uses levadopa?
- CNS disorder
- variety of presentations
- muscle atrophy
- normal cognition
- test performed along the lateral side of sole of foot
- upper motor neuron sign
- indicative of pyramidal tract damage
- bladder incontinence
- heat intolerant
- bowel and bladder
- frontal cortex
- temporal lobe
- frontal lobe
- learning is lost
- eating disturbance
- sleep disturbance
- masked face
- postural reflex embarrassment
- decrease in fine motor skills
- interferon beta
- Lhermitte's sign
- sustained muscle contractions
- botox injection may help
Changes in the lateral aspect of the spinal cord, brain stem, cerebral cortex.
- motor neuron degeneration & scarring
- peripheral nerve damage
- muscle fiber atrophy
Plaques & tangles
Cognitive deficits with denial of memory problems, subtle personality as mobility & ADL intact.
- Cortical atrophy involving predominantly the frontal and temporal regions with sparing of the posterior 2/3.
- Much less common and sometimes clinically indistinguishable from Alzheimer's.
Loss of inhibition of socially unacceptable and previously supressed behavior which emerges early in the disease often overshadowing the memory disturbance.
Neurons balloon in the area of involved tissue, but there are not the plaques or tangles seen in AD.
- Initial parkisonism unresponsive to standard medications, progressing to deterioration of cognition.
- Dementia is usually a late manifestation of the disease.
Lewy body dementia
- New lesions appear at previously attacked sites
- Lesions can be acute or chronic.
- Secondary progressive
- Primary progressive
- Progressive relapsing
Stages of MS
The most common manifestation of Parkinson's disease.
- present at rest
- has a regular rhythm
- doesn't interfere with ADLs
- decreases or disappears with movement
Lewy bodies within the substantia nigra.
- Atrophy of the caudate nucleus and putamen.
- Leads to enlarged ventricles.
- Acetylcholine is reduced.
- Dopamine is increased.
- Loss of controlled movement.
- Autosomal dominant
- Each child has a 50% chance
- Tip of chromosome 4
- familial (rare)
- new variant (related to mad cow diesase)
Types of CJD
Much less common and sometimes indistinguishable from AD.
This disorder exhibits highly variable clinical and neuropathologic overlap with AD and PD.
Lewy Body Dementia
- too much dopamine and norepinephrine
- too little acetylcholine and GABA
There is an excess of dopamine and excessive excitation of the thalamocortical pathway, which explains the excessive movement.
HD - enlargement of lateral ventricles
- Sporadic neurodegenerative disorder
- Loss of midbrain dopamine neurons
- Presence of Lewy body inclusions
Which 2 diseases are commonly involved with dementia?
HD & AD
Which 2 diseases has unwanted movements?
Dystonia & HD
Which 2 diseases have increased incidence in particular climates?
ALS & MS
Which 2 diseases can be drug induced?
Dystonia & PD
Which 2 diseases have abnormal protein?
CJD & AD
Which 2 diseases are involved with depression?
HD & PD