What is Drug hypersensitivity syndrome?
Drug hypersensitivity syndromes are classically associated with anticonvulsants, allopurinol, dapsone, and NSAIDs. They begin 3 to 6 weeks after the initiation of therapy. Angiotensin-converting enzyme inhibitors (lisinopril) are not commonly associated with hypersensitivity drug eruptions. In addition, patients with hypersensitivity drug eruptions typically present with widespread erythema that evolves over weeks rather than days and skin that is itchy more than painful, as well as facial swelling, lymphadenopathy, eosinophilia, atypical lymphocytosis, and elevated aminotransferases.