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shosh114
on FreezingBlue Flashcards.
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Cancer associated with Down's syndrome
ALL
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Tuberous sclerosis--presentation and associated cancers
- Presents wtih facial angiofibromas, seizures, and retardation
- Associated with astrocytoma, angiomyolipoma, and cardiac rhabdomyoma
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Cancer associated with actinic keratosis
Squamous cell carcinoma
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Presentation of Plummer-Vinson syndrome and associated cancer
- Present wtih glossitis, esophageal webs, and iron-deficient anemia
- Associated with squamous cell carcinoma of the esophagus
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Cancer associated with immunodeficiency
Lymphoma
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Acanthosis nigricans
Indicates visceral malignancy
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Cancer associated with exposure to radiation
Papillary thyroid carcinoma
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Cancer associated with achalasia
Squamous cell carcinoma of the esophagus
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abl
- Oncogene
- Codes for an RTK
- Associated with CML
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c-myc
- Oncogene
- Codes for an intranuclear transcription factor
- Associated with Burkitt's
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bcl-2
- Oncogene
- Anti-apoptotic protein
- Associated with follicular carcinoma
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erb B2
- Oncogene
- Codes for an RTK
- Associated with breast, ovarian, and gastric cancer
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ras
- Oncogene
- Codes for a GTPase involved in the MAP kinase pathway
- Associated with colon cancer
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L-myc
- Oncogene
- Codes for a transcription factor
- Associated with lung cancer
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n-myc
- Oncogene
- Codes for a transcription factor
- Associated with neuroblastoma
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ret
- Oncogene
- Codes for an RTK
- Associated with MEN I and MEN II
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c-kit
- Onocgene
- Codes for a cytokine receptor
- Associated with GIST
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Rb
- Tumor suppressor gene
- Blocks G1-->S transition
- Associated with retinoblastoma and osteosarcoma
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BRCA1 and 2
- Tumor suppressor gene
- Associated with breast (BRCA1) and ovarian cancer
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p53
- Tumor suppressor gene
- Blocks G1-->S transition
- Mutated in Li Fraumeni
- Seen in many cancers
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p16
- Tumor suppressor gene
- Mutated in melanoma
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APC
- Tumor suppressor gene
- Blocks mitosis before anaphase
- Mutated in colorectal cancer
- Associated with FAP
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WT1
- Tumor suppressor gene
- Associated with Wilm's tumor
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DPC
- Tumor suppressor gene
- Associated with pancreatic cancer
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DCC
- Tumor suppressor gene
- Associated with colon cancer
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S-100 tumor marker
Associated with melanoma, meningioma, and astrocytoma
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What could elevated alk phos indicate?
- Paget's disease of the bone
- Obstructive biliary disease
- Bone metastases
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Bombesin
Marker for neuroblastoma, lung cancer, and gastric cancer
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TRAP
Marker for hairy cell leukemia (B cell cancer)
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CA-19-9
Marker for pancreatic cancer
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Aflatoxin
- Produced by aspergillus
- Associated with HCC
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Vinyl chloride
Associated with hepatic angiosarcoma
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CCl4
Asssociated with centrilobular necrosis and fatty change of the liver
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Nitrosamines
Associated with esophageal and gastric cancer
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Arsenic
Associated with squamous cell carcinoma of the skin and liver angiosarcoma
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Napthele (aniline) dyes, found in mothballs
Associated with bladder cancer
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Cancers associated with psammoma bodies
- Meningioma
- Papillary thyroid carcinoma
- Malignant mesothelioma
- Serous adenocarcinoma of the ovaries
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Decreased ESR
Seen in sickle cell, polycythemia, and CHF
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Blastic bone metastases
Prostate cancer
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Blastic and lytic bone metastases
Breast cancer
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