shosh: neoplasia

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shosh114
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96065
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shosh: neoplasia
Updated:
2011-08-03 16:17:08
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  1. Cancer associated with Down's syndrome
    ALL
  2. Tuberous sclerosis--presentation and associated cancers
    • Presents wtih facial angiofibromas, seizures, and retardation
    • Associated with astrocytoma, angiomyolipoma, and cardiac rhabdomyoma
  3. Cancer associated with actinic keratosis
    Squamous cell carcinoma
  4. Presentation of Plummer-Vinson syndrome and associated cancer
    • Present wtih glossitis, esophageal webs, and iron-deficient anemia
    • Associated with squamous cell carcinoma of the esophagus
  5. Cancer associated with immunodeficiency
    Lymphoma
  6. Acanthosis nigricans
    Indicates visceral malignancy
  7. Cancer associated with exposure to radiation
    Papillary thyroid carcinoma
  8. Cancer associated with achalasia
    Squamous cell carcinoma of the esophagus
  9. abl
    • Oncogene
    • Codes for an RTK
    • Associated with CML
  10. c-myc
    • Oncogene
    • Codes for an intranuclear transcription factor
    • Associated with Burkitt's
  11. bcl-2
    • Oncogene
    • Anti-apoptotic protein
    • Associated with follicular carcinoma
  12. erb B2
    • Oncogene
    • Codes for an RTK
    • Associated with breast, ovarian, and gastric cancer
  13. ras
    • Oncogene
    • Codes for a GTPase involved in the MAP kinase pathway
    • Associated with colon cancer
  14. L-myc
    • Oncogene
    • Codes for a transcription factor
    • Associated with lung cancer
  15. n-myc
    • Oncogene
    • Codes for a transcription factor
    • Associated with neuroblastoma
  16. ret
    • Oncogene
    • Codes for an RTK
    • Associated with MEN I and MEN II
  17. c-kit
    • Onocgene
    • Codes for a cytokine receptor
    • Associated with GIST
  18. Rb
    • Tumor suppressor gene
    • Blocks G1-->S transition
    • Associated with retinoblastoma and osteosarcoma
  19. BRCA1 and 2
    • Tumor suppressor gene
    • Associated with breast (BRCA1) and ovarian cancer
  20. p53
    • Tumor suppressor gene
    • Blocks G1-->S transition
    • Mutated in Li Fraumeni
    • Seen in many cancers
  21. p16
    • Tumor suppressor gene
    • Mutated in melanoma
  22. APC
    • Tumor suppressor gene
    • Blocks mitosis before anaphase
    • Mutated in colorectal cancer
    • Associated with FAP
  23. WT1
    • Tumor suppressor gene
    • Associated with Wilm's tumor
  24. DPC
    • Tumor suppressor gene
    • Associated with pancreatic cancer
  25. DCC
    • Tumor suppressor gene
    • Associated with colon cancer
  26. S-100 tumor marker
    Associated with melanoma, meningioma, and astrocytoma
  27. What could elevated alk phos indicate?
    • Paget's disease of the bone
    • Obstructive biliary disease
    • Bone metastases
  28. Bombesin
    Marker for neuroblastoma, lung cancer, and gastric cancer
  29. TRAP
    Marker for hairy cell leukemia (B cell cancer)
  30. CA-19-9
    Marker for pancreatic cancer
  31. Aflatoxin
    • Produced by aspergillus
    • Associated with HCC
  32. Vinyl chloride
    Associated with hepatic angiosarcoma
  33. CCl4
    Asssociated with centrilobular necrosis and fatty change of the liver
  34. Nitrosamines
    Associated with esophageal and gastric cancer
  35. Arsenic
    Associated with squamous cell carcinoma of the skin and liver angiosarcoma
  36. Napthele (aniline) dyes, found in mothballs
    Associated with bladder cancer
  37. Cancers associated with psammoma bodies
    • Meningioma
    • Papillary thyroid carcinoma
    • Malignant mesothelioma
    • Serous adenocarcinoma of the ovaries
  38. Decreased ESR
    Seen in sickle cell, polycythemia, and CHF
  39. Blastic bone metastases
    Prostate cancer
  40. Blastic and lytic bone metastases
    Breast cancer

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