Drugs

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Author:
rebekahsessoms
ID:
96412
Filename:
Drugs
Updated:
2011-08-08 11:00:17
Tags:
Cell Science Drugs
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Description:
Cell Science
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  1. Causes misreading of the genetic code. Interferes with initiation
    • Streptomycin
    • In Prokaryotes
  2. Inhibits binding of aminoacyl-tRNA to A-site
    • Tetracycline
    • In Prokaryotes
  3. Inhibits peptidyl transferase activity on ribosomes
    • Choramphenicol
    • In Prokaryotes
  4. Binds to the 50S subunit and inhibits translocation.
    • Erythromycin
    • In Prokaryotes
  5. Resembles aminoacyl-tRNA and binds ot the A-site.
    Causes premature release of the polypeptide chain.
    • Puromycin
    • In Eukaryotes and Prokaryotes
  6. Inhibits peptidyl transferase activity of the 60S
    • Cyclohexamide
    • In Eukaryotes
  7. Inhibits eEF-2 and prevents translocation.
    • Diptheria toxin.
    • In Eukaryotes
  8. Inactivates 60S subunit of the ribosome.
    • Ricin
    • In Eukaryotes
  9. Streptomycin
    • Causes misreading of the genetic code.
    • Interferes with initiation in Prokaryotes.
  10. Tetracycline
    • Inhibits binding of aminoacyl-tRNA to A-site.
    • In Prokaryotes
  11. Choramphenicol
    Inhibits peptidyl transferase activity on ribosomes in Prokaryotes.
  12. Erythromycin
    Binds to the 50S subunit and inhibits translocation in Prokaryotes.
  13. Puromycin
    • Resembles aminoacyl-tRNA and bines ot the A-ste.
    • Causes premature relase of polypeptide chains in Prokaryotes and Eukaryotes.
  14. Cyclohexamide
    Inhibits peptidyl tranferase activity of the 60S ribosome in Eukaryotes.
  15. Diptheria toxin
    Inhibits eEF-2 and prevents translocation in Eukaryotes.
  16. Ricin
    Inactivates 60S subunit of ribosome in Eukaryotes.
  17. Norfofloxacin
    Affects DNA gyrase in bacterial DNA replication.
  18. Ziovudine
    Affects reverse transcriptase. Used in AIDS patients.
  19. AZT (3'-azido-3'-deoxythymidine)
    Inhibits reverse transcriptase.
  20. Alpha - amantinin
    Affects trascription...RNA-PolII is EXTREMELY SENSITIVE to this drug.
  21. Rifampicin
    Inhibits RNA synthesis in Prokaryotes, by binding to the Beta subunit. Does NOT affect eukaryotic RNA synthesis.
  22. Actinomycin-D
    NOT specific for either prokaytoes or eukaryotes, so is not a good drug. Binds tightly to dsDNA and inhibits RNA synthesis.

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