Med Chem Exam II

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Anonymous
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9649
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Med Chem Exam II
Updated:
2010-03-08 17:48:14
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Chapter 8
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Sulfonilamides
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  1. Protonsil
    • inactive on bacterial cultures
    • reduced invivo to yield sulfonilamide
    • example of prodrug
  2. Sulfonamide
  3. Sulfanilamide
    • pKa = 10.4
  4. Reducing Crystalluria
    • 1. Increase urine flow by forcing fluids
    • 2. Raise the pH of the urine with bicarb
    • 3. Use derivatives of sulfanilamide that have lower pKas
    • 4. Mix sulfonamides to reach the total dose.
    • Trimethoprim
    • Inhibits Folate Reductase in the Folate biosynthesis pathway.
  5. Toxicity and side effects
    • Drug Fever
    • Hemolytic anemia
    • crystalluria
    • Sulfacetamide
    • pKa 5.4
  6. Sulfapyridine
    • pKa 8.4
  7. Sulfadiazine
    • pKa 6.3
  8. PABA
  9. Sulfamerazine
    • pKa = 6.8
  10. Sulfamethazine
    • pKa=7.2
  11. Trisulfapyrimidines
    Mixture of sulfadiazine, sulfamerazine and sulfamethazine
    • Sulfasalazine
    • prodrug for sulfapyridine
    • Trimethoprim
    • Folic Acid Biosynthesis Pathway
    • Acts on Folate Reductase
    • Dapsone
    • Leprosy

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