epinephrine

Card Set Information

Author:
sulliva7
ID:
96724
Filename:
epinephrine
Updated:
2011-08-10 17:24:12
Tags:
epinephrine Adrenalin
Folders:

Description:
Adrenalin
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  1. Functional Class
    Sympathomimetic
  2. How it's supplied
    1:1,000 (1mg of epi in 1ml or 1mg/ml)

    1:10,000 (1mg of epi in 10ml or 0.1mg/ml)
  3. MOA
    • 1) Naturally occuring catecholamine that acts directly on the alpha and beta (more profound) adrenergic receptors.
    • 2) This causes positive inotropic, dromotropic and chronotropic effects
    • 3) Increases systemic vascular resistance and BP
  4. Indications
    • 1) Caridac arrest: asystole, VF, pulseless VT, PEA
    • 2) Symptomatic bradycardia
    • 3) Anaphylaxis
    • 4) Severe reactive airway disease
  5. Contraindications
    Hypersensitivity to sympathomimetic amines

    (*amine - class of compounds derived from ammonia by replacement of one or more H atoms with organic groups)
  6. Precautions
    • 1) Protect from light
    • 2) Can be deactivated by sodium bicarb, flush line between admin of epi and sodium bicarb
    • 3) Effects intensified by antidepressants
  7. Side Effects
    • 1) Increases myocardial oxygen demand
    • 2) Can cause; anxiety, H/A, CVA
    • 3) Syncope, HTN, tachydysrhythmias
    • 4) Tissue necrosis with repeated injections or extravasation of IV
  8. Interactions
    • 1) May increase hypotension caused by phenothiazines, alpha and beta blockers.
    • 2) Can be deactivated in alkaline solutions or sodium bicarb
  9. Dose/Route
    • Cardiac Arrest:
    • Adult: 1.0 mg 1:10,000 IVP q 3-5 mins or 2.0-2.5 mg ET q 3-5 mins of 1:1,000 (diluted to 10ml)
    • Pedi: 0.01mg/kg of 1:10,000 IV/IO or 0.1 mg/kg of 1:1,000 ET q 3-5 min (diluted to 3-5ml)

    • Severe Anaphylaxis/Asthma:
    • Adult: 0.3-0.5mg SQ of 1:1,000 q 5-15 mins
    • if ineffective give:
    • 0.1-0.5mg of 1:10,000 IVP q 5-15 min

    • Pedi: 0.01mg/kg of 1:1,000 SQ
    • if ineffective give:
    • 0.01mg/kg of 1:10,000 IVP q 5-15 mins

    • Symptomatic Bradycardia Infusion:
    • Preparation: 1mg of 1:1,000 in 250 ml NS
    • Adult: 2-10 mcg/min

    Pedi: 0.1-1 mcg/kg/min

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