Card Set Information
Abx and pharm
Which gram stain is strep spp?
Which gram stain is staph spp?
Which gram stain is enterococcus?
Which gram stain is klebsiella?
Which gram stain is serratia?
Which gram stain is proteus?
Which gram stain is salmonella?
Which gram stain is H flu?
Which gram stain is Legionella?
Which gram stain is neisseria spp?
Which gram stain is pseudomonas?
What is the MOA of PCNs?
They inhibit the cell wall by binding to PCN binding proteins and inhibiting enzymes that create the cross-linkages
What are ADRs to PCNS?
Hypersensitivity reactions (anaphylaxis, hemolytic anemia, serum sickness)
Describe the absorption of PCNs
When do they reach peak concentrations?
Most are destroyed by gastric acid
They are absorbed in the duodenum and reach peak concentrations in 1-2 hours
Describe how PCNs are eliminated
70% are excreted by the kidneys
T1/2 approx 1 hour
How does PCN resistance come about?
inactivation by various beta-lactamases
development of new PCN binding proteins that have decreased affinity for PCNs
List the GM+ organisms covered by PCNs
Lis the GM- organisms covered by PCNs
List the anaerobic organisms that PCNS cover
PCNs are the drugs of choice for which conditions?
All stages of syphilis and strep infectinos
Name the PCNase resistant PCNs
Oxacillin, nafcillin, dicloxacillin
What organisms do PCNase resistant PCNs cover?
What isn't covered?
Strep, staph, peptostreptococcus (better staph coverage than nl PCNS)
When do you dose adjust for the PCNase PCNs?
severe hepatic impairment
Name the two aminoPCNs
What are the drugs of choice against enterococcal infections?
aminoPCNs (ampicillin, amoxacillin)
Describe the aminoPCN stability around beta lacatamase
not very beta-lactamase stable
What drug class does ticarcillin belong to?
What organisms does ticarcillin cover?
Gram-, esp. pseudomonas
What drug class does piperacillin belong to?
What organisms does piperacillin cover?
Strep and enterococcus
Usual anaerobes PLUS BACTEROIDES
Describe piperacillin's activity with staph
NO ACTIVITY with staph
Name the beta-lactamase inhibitors
Unasyn is a combo of:
Augmentin is a combo of:
Timentin is a combo of:
Zosyn is a combo of:
How are the beta-lactamase inhibitors better than piperacillin?
Improves GM- against H flu, M. cat, N. gonorrhea, as well as bacteroides
Describe cephalosporin coverage of enterococcus
What are ADRs to