neuromuscular blocking agent
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neuromuscular blocking agents block
nicotinicM receptors at the neuromuscular junction.
The ganglionic blocking agents block
nicotinicN receptors in autonomic ganglia.
Neuromuscular blockers interfere with
nicotinicM receptor activation and thereby cause muscle relaxation.
Nondepolarizing neuromuscular blockers act by competing with
acetylcholine (Ach) for binding to nicotinicM receptors.
the only depolarizing neuromuscular blocker in use
Succinylcholine binds to
causing the end-plate to depolarize; the drug then remains bound, which keeps the end-plate from repolarizing.
Neuromuscular blockers are used to produce
- muscle relaxation during surgery,
- endotracheal intubation,
- mechanical ventilation,
- electroshock therapy.
Paralysis is brief because succinylcholine is
rapidly degraded by pseudocholinesterase, an enzyme present in plasma.
Neuromuscular blockers do not reduce
consciousness or pain
The major adverse effect of neuromuscular blockers is
Succinylcholine can cause
malignant hyperthermia, a life-threatening condition.
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