Card Set Information

2011-08-12 13:44:12
Medic Meds

National Registry Medications
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  1. Acetaminophen
    Classes: Analgesic; Antipyretic
  2. Trade Names:
    Acenal (Can), Acephen, Aceta, Actamen, Actimol ( Can), Anacin-3, Anuphen, Apacet, APAP, Atasol ( Can), Banesin, Dapa, Datril, Dolanex. DOrcol. Dymadon ( Aus), Exdol (Aus), Fecerall, Genpap (Can), Genebs, Halenol, Liquiprim, Maoao, Medacap, Neopap, Oraphen, Panadol, Panamax (Aus), Panex, Paralgin (Aus), Pedric, Redutemp, Robigesic (Can), Rounox (Can), Snaplets, St. Josephs Children's, Supap, Tapanol, Tempra, Tenol, Tylenol, Typap, Valdol, Valorin
  3. Action/Pharmacodynamics:
    Acetaminophen is a clinically proven anlgesic/antipyretic. Acetaminophen produces analgesia by elevation of the pain threshold and antipyresis through action on the hypothalamic heat regulating center. Acetaminophen is equivalent to aspirin in analgesic and antipyretic efectiveness. Unlike aspirin, acetaminophen has little effect on pplatelet function, does not affect bleeding time and generally does not produce no gasric effects associated with aspirin and aspirin containing products.
  4. Emergency Uses:
  5. Aceminophen is used as a substitiue for aspirin, when the latter is not tolerated or is contraindicated. to reduce fever and or to temporairly releive mid to moderate pain
    • Dose: Adult: 325-650 mg PO every 4-6 hours, max 4 g/day.
    • Pediatrics: 15 mg Kgevery 4-6 hours.
  6. Pharmokinetics:
    Absorbtion: Rapid and almost compete absorption ( 60%-70%) from GI Tract; Less complete absorbtion ( 30%-40%) from rectal suppository; peak effect in 1-2 hours duration is 3-4 hours.
  7. Half Life:
    is 1-3 hours.
  8. Distribution:
    Well distributed in all body fluids; crosses placenta.
  9. Metabolism:
    Extensively metabolized in LIVER.
  10. Elimination:
    Excreted as metabolites in urine, excreted in breast milk.
  11. Contrindication and Precautions:.
    Acetaminophen is contraindicated in patients with hypersensitivity. It is also contraindicateid in children under 3 yeas unless directed by a physician. Acoid repeated administratio to patients with anemia or hepatic disease Use with caution in arthritic or rhumatoid conditions affecting children under 12 years, Alcoholism, Malnutrition, Thrombocytopenia
  12. Adverse/Side:
    Acute poisoning, CNS, Dizziness, lethargy, GI, Anorexia, nausea, vomiting, epigastricm or coma, acute renal failure (rare), OTHER; diaphoresis, chills, elecation of serym transaminaese, (ALT, AST) and biliruben, hypoglycenmia.
  13. Interactions:
    With chronic coadministration, barbituates, carbamazepine, phenytoin and rifampin may increase the potential for chronic hepatoxicity, Chronic Excessice ingestion witll increase the risk of hepatooxicity.
  14. Prehospital Considerations:
    1. Individuals with poor nutrition who have ingested alcohol over prolonged periods are prone to hepatotoxicity even from moderate acetaminophen doeses. 2. Overdosing and chronic use can cause liver damage and other toxic effects. 3. Acetaminophen should not be used for self-medication of pain for more than 10 days in adults or for more than 5 days in children without consulting a physician. It should not be used for fecer persisiting longer than 3 days and never for fever over persisiting longer than 2 days and never for fever over 39.5 (103F)or for recurrent fever without medical direction. No more than 5 doses in 24 hours should be given to children unless prescribed by physician.