Drugs.txt

Card Set Information

Author:
brooke.elizabeth21
ID:
96966
Filename:
Drugs.txt
Updated:
2011-08-13 19:33:04
Tags:
Epinephrine
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Description:
Epinephrine
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  1. Generic/Trade Name
    Epinephrine/
  2. Class
    Sympathetic agonist
  3. Description
    • Acts directly on alpha- and beta-adrenergic receptors
    • Effects on beta-recepetors are much more profound that effects on alpha-receptors
    • Effects include:
    • Increased heart rate
    • Increased cardiac contractile force
    • Increased electrical activity in the myocardium
    • Increased SVR
    • Increased blood pressure
    • Increased automaticity
    • Can be used to convert fine v-fib to coarse v-fib. (increases chance of successful shock)
    • In asystole it's used to initiate electrical activity in myocardium
  4. Pharmacokinetics
    • Onset: <2 minutes (IV/ETT)
    • Peak Effects: <5 minutes (IV/ETT)
    • Duration: 5-10 minutes (IV/ETT)
    • Half-life: 5 minutes
  5. Indications
    • Cardiac arrest (asystole, v-fib, pulseless v-tach, PEA)
    • Severe anaphylaxsis
    • Severe reactive airway disease
  6. Contraindications
    • 1:10,000 contraindicated in patients who do not require extensive cardiopulmonary resuscitation.
    • 1:1,000 sub-q is fine for simple allergic reactions and asthma
  7. Precautions
    • Protect from light
    • Can be deactivated by alkaline solutions (flush line in-between)
  8. Side Effects
    • Palpatations
    • Anxiety
    • Tremulousness
    • Headache
    • Dizziness
    • Nausea
    • Vomiting
    • Increases myocardial oxygen demand (can cause ischemia)
  9. Interactions
    • pH dependant (can be deactivated by alkaline solutions)
    • Effects can be intensifed by patients taking antidepressents
  10. Dosage:
    • Epinephrine can be administered IV, IO, or
    • through the ETT

    • Cardiac arrest adult:
    • 1.0mg of 1:10,000 solution IV
    • Repeat every 3-5 minutes as needed
    • If given through ETT, does should be 2-2.5x the IV dose

    • Cardiac arrest pediatrics:
    • 0.01mg/kg of 1:10,000 solution IV (0.1mL/kg)
    • 2nd and subsequent doses should be 0.1mg/kg of 1:1,000 solution (0.1mL/kg)

    • Severe anaphylaxis or severe asthma adult:
    • IV epinephrine should only be used in life-threatening emergencies
    • Use initial does of 0.3-0.5mg IV
    • Can be repeated 5-15 minutes as needed
    • Epinephrine drip may be needed
    • Less severe cases can be treated with epinephrine 1:1,000 subcutaneously.

    • Severe anaphylaxis or severe asthma children:
    • IV epinephrine should only be used in life-threatening emergencies
    • Use initial does of 0.01mg/kg IV
    • Can be repeated 5-15 minutes as needed
    • Epinephrine drip may be needed
    • Less severe cases can be treated with epinephrine 1:1,000 subcutaneously.

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