24 Drugs

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Author:
Jme
ID:
97010
Filename:
24 Drugs
Updated:
2011-08-14 07:54:24
Tags:
Reproductive drugs
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Description:
Drugs
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  1. Reproductive drugs in four categories are
    • Gonadotrophic
    • Androgens
    • Estrogens
    • Progestins
  2. Gonadotrophic hormones include

    male gonads are testes
    female gonads are ovaries

    corpus luteum - follicle after a woman ovulates
    • Follicle-stimulating hormone (FSH)
    • Luteinizing hormone (LH)
    • Luteotrophic hormone (LTH)

    • FSH - which stimulates development of ovarian follicles in the female and sperm production in the testes of the male
    • LH - works in conjunction with FSH to induce secretion of estrogen, ovulation, and development of the corpus luteum
    • LTH - stimulates the secretion of progesterone by the corpus luteum and secretion of the milk by the mammary gland, hence the term lactogenic hormone
  3. The male hormones, are secreted mainly in the interstitial tissue of the testes in the male secondarily in the adrenal glands of both sexes are
    Adrogens
  4. Stimulate the development of male characteristics (maculinization)
    Adrogens
  5. Masculinziation include
    Testosterone and androsterone
  6. Inadequate production of adrogens in a male may be due to
    • Pituitary malfunction
    • Atrophy
    • Injury or removal of testicles (castration)
    • Eunchism
    • Eunuchoidism
  7. This characteristic includes retarded development of sex organs, absence of beard and body hair, high pitched voice, lack of muscular development
    Eunuchoid
  8. This may result in impotence or deficient sperm production is
    Hypogonadism
  9. Uses of androgens include:
    • Replacement
    • Acquired
    • Palliative treatment

    Congenital

    • 1. in cases of diminished testicular hormone with testosterone (e.g. impotence, oligospermia, and andropause (male menopause)
    • 2. hypogonadism (e.g. cryptorchidism or undescended testicles) or delayed puberty in the male
    • 3. hypogonadism (e.g. orchitis, trauma, tumor, radiation, surgery of the testicles, or drug induced(
    • 4. of females with advanced metastatic (Skeletal) carcinoma of the breast for examp, methytestosterone
  10. SE:
    Edema
    Acne
    Hirsutism - unusal hair growth
    Gynecomastia
    Jaundice and hepatitis
    N/V
    Premature closure of bone ends
    Stunt growth
    Anxiety, Depression, HA
    Increased LDL
    Decreased HDL
    Androgens side effects
  11. Contraindications with adrogens are
    • Cardiac
    • Renal
    • Liver dysfunction - edema
    • Growth of cancerous tissue
    • Prepubertal males
    • Diabetes
    • Obesity
  12. Interactions with of adrogens are
    • Oral anticoagulants
    • Decreased blood glucose
    • Antiadrogens (dutasteride/finasteride)

    1. potentiation may cause bleeding
  13. Androgen drugs

    Generic/Tradename/Dosage
    1. danazol/Danocrine
    2. methytestosterone/Android, Testred
    w/estrogen/Estratest
    3. oxandrolone/Oxadrin
    4. testosterone/Depo-Testosterone
    /Androderm, AndroGel
    • Doses and uses
    • 1. 100-400mg/endometriosis, fibrocystic, breast disease
    • 2. PO, buccal does varies, PO, dose varies/Advanced breast ca; replacement therapy, Menopausal sx if estrogen alone insufficient
    • 3. Tx of cachexia
    • 4. Hypogonadism, advanced breast ca
  14. The female sex hormones, are produced mainly by the ovary and secondarily bby the adrenal glands
    Estrogens
  15. Responsible for the development of female secondary sexual characteristics, including breast enlargement, during a menstrual cycle they act on the female genitalia to produce an environment suitable for fertalization, implantation and nutrition of the early embryo
    Estrogens
  16. Secrete hormones such as FSH and LH from the anterior pituitary gland in a complex way
    Estrogens
  17. Estrogen is used in combination with what in order of management of severe menopausal sx that do not respond to estrogen alone is
    Testosterone
  18. SE:
    Thromboembolic disorders
    HYPERtension
    MI
    stroke
    V/D
    Weight gain
    Folic acid deficiencies
    HA
    Depression
    Ca of the uterus
    Estrogens
  19. A hormone secreted by the corpus luteum (ovary) and adrenal glands is
    Progesterone
  20. SE:
    Menstrual irregularity

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