PHARM_MSII_DOC_FUNG_WORM_PROT_MALARIA

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soren101
ID:
97076
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PHARM_MSII_DOC_FUNG_WORM_PROT_MALARIA
Updated:
2012-04-23 22:38:17
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PHARMACOLOGY MSII DOC FUNGAL
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PHARMACOLOGY MSII DOC FUNGAL
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  1. CANDIDEMIA
    (UNTREATED PATIENT IN ICU)
    TREAT I.V. WITH A -FUNGIN, E.G. CASPOFUNGIN, UNTIL BLOOD CULTURE REVEALS SUSCEPTIBILITY;

    IF CANDIDA IS SUSCEPTIBLE TO -AZOLES, THEN DISCONTINUE THE CASPOFUNGIN

    START I.V. OR P.O. FLUCONAZOLE, DEPENDING ON THE STATUS OF THE PATIENT'S GI TRACT
  2. CANDIDEMIA
    (Pt ALREADY HAS BEEN TREATED WITH AN -AZOLE RECENTLY)
    A FUNGIN, E.G., CASPOFUNGIN I.V.
  3. CANDIDEMIA
    (CULTURES SHOW -AZOLE RESISTANCE)
    A FUNGIN, E.G., CASPOFUNGIN I.V.
  4. CANDIDEMIA
    (PATIENT "ON THE FLOOR" AND CLINICALLY STABLE, I.E. IN THE GENERAL MEDICINE WARD)
    FLUCONAZOLE, P.O.
  5. CANDIDA KRUSEI
    A FUNGIN, E.G., CASPOFUNGIN I.V.,

    OR

    I.V. VORICONAZOLE
  6. ASPERGILLOSIS
    • VORICONAZOLE
    • I.V. OR P.O.
  7. ZYGOMYCETES
    I.V. AMPHOTERICIN INITIALLY,

    CHANGE TO P.O. POSACONAZOLE WHEN THE PATIENT IS DISCHARGED
  8. COCCIDIODES IMMITIS
    FLUCONAZOLE
  9. Pt w AIDS HAS MENINGITIS CAUSED BY CRYPTOCOCCUS NEOFORMANS, A.K.A. "CRYPTO" MENINGITIS
    I.V. AMPHOTERICIN B + P.O. FLUCYTOSINE
  10. (NOTE: FLUCYTOSINE ONLY AVAILABLE IN ORAL FORM),
  11. THEN P.O. FLUCONAZOLE FOR LIFE
  12. NICLOSAMIDE
    UNCOUPLES OXIDATIVE NETABOLISM

    TAPEWORM SCOLEX RELEASES FROM INTESTINAL WALL
  13. PRAZIQUANTAL
    OPENS Ca CHANNELS TO CAUSE MUSCULAR TETANY

    SPASTIC PARALYSIS

    CAUSES TEGMENTAL DAMAGE WHICH ACTIVATES HOST IMMUNE SYSTEM
  14. 'AZOLS
    INH SYNTH OF MICROTUBULES NEEDED FOR GLUC UPTAKE

    DEC GLYCOGEN AND ATP --> DEATH
  15. DIETHYLCARBAMAZINE
    IMMOBILIZES MICROFILARIAE VIA DEC MUSC ACTIBITY

    ALTERS SURFACE MEM TO MAKE ORG MORE SUSCEPTIBLE TO HOST IMMUNE DEFENCES
  16. PYRANTEL PAMOATE
    GANGLIONIC NICOTINIC CHOLINERGIC AGONISTS --> MUSC TETANY

    ~ORGANOPHOS POISON N2 REC
  17. IVERMECTIN
    BINDING TO GLUT-GATED Cl- CHANNEL (INVERTEBRATES ONLY)

    INC Cl- CONDUCTANCE --> HYPERPOL CAUSES TONIC PARALYSIS OF MUSCULATURE
  18. Tx ASCARIS LUMBRICOIDES
    ROUNDWORM

    MEBENDAZOL, ALBENDAZOLE

    PYRANTEL PAMOATE
  19. Tx ENTEROBIUS BERMICULARIS
    PINWORM

    MEBENDAZOLE

    PYRANTEL PAMOATE
  20. Tx NECATOR AMERICANUS
    HOOKWORM

    ALBENDAZOLE, MEBENDAZOLE

    PYRANTEL PAMOATE
  21. Tx TRICHURIS TRICHIURA
    WHIPWORM

    ALBENDAZOLE, MEBENDAZOLE
  22. Tx STRONGYLOIDES STERCORALIS
    THREADWORM

    IVERMECTIN DOC

    THIABONDAZOLE, ALBENDAZOLE
  23. Tx TRICHENELLA SPIRALIS
    TRICHINOSIS

    THIABENDAZOLE, ALBENDAZOLE
  24. Tx WUCHERIA BANCROFTI
    FILARIAE

    DIETHYLCARBAMAZINE

    ELEPHANTITIS
  25. Tx ONCHOCERCA VOLVULUS
    FILARIAE

    IVERMECTIN

    RIVER BLINDNESS
  26. 3 BUGS KILLED w IVERMECTIN
    ONCHOCERCIASIS, STONGYLOIDASIS, ECTOPARASITES (SCABIES)
  27. Tx CESTODES
    TAPEWORM

    NICLOSAMIDE

    PRAZIQUANTAL DOC IN REAL LIFE

    ALBENDAZOLE DOC FOR NEUROCYSTICERCOSIS
  28. Tx SCHISTOSOMA
    FLUKE

    PRAZIQUANTEL
  29. Tx GIARDIA
    METRONIDAZOLE
  30. Tx TRICHOMONAS
    METRONIDAZOLE
  31. Tx ENTAMOEBA HISTOLYTICA
    AMEBIASIS

    METRONIDAZOLE
  32. S/E METRONIDAZOLE
    DISULFIRAM-LIKE REACTION

    INH ALD DEHYDROGENASE

    TERATOGENIC
  33. Tx PCP
    TRIM SULFA

    • IF ALLERGIC -- PENTAMIDINE ISETHIONATE
    • MOA UNK
  34. Tx MALARIA
    CHLOROQUINE

    • IF RESISTANT
    • --MEFLOQUINE (PSYCH PROBS)

    PRIMAQUINE FOR LIVER

    • ACUTE HEMOLYSIS WHEN Tx w PRIMAQUINE?
    • --G6PD DEFICIENCY
  35. KETOCONAZOLE
    • INH FUNGAL CYP450
    • --INH DEMTHYLATION OF LANOSTEROL TO ERGOSTEROL

    • CAN'T USE w AMPHO-B
    • --BLOCKS MOA

    Tx CANDIDA & COCCIDIOIDES

    • INH ADRENAL 17a & SCC CYP450
    • --ADREN INSUFFICIENCY AND DEC TESTOST & EST
  36. FLUCYTOSINE
    CONVERTED TO FLUOROURACIL

    INH THYMIDYLATE SYNTH --> INH DNA SYNTH

    RESISTANCE DEVs RAPIDLY SO ALWAYS GIVEN w AMPHO

    SELECT TOX TO FUNGI bc MAM CELLS UNABLE TO CATAB DEAMINATION

    S/E BONE MARROW SUPPRESSION

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