TH subsets, cytokines

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Author:
Anonymous
ID:
97610
Filename:
TH subsets, cytokines
Updated:
2011-08-19 20:03:17
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cytokines cells effectors
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Description:
MS1/Mod 1: immunology, TH subsets and cytokines
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  1. IL-2
    TH1

    • supports T cell growth
    • MHC1/2 growth maintenance
  2. IFN-gamma
    TH1

    enhances inflam; act phagocytes; suppresses TH2 responses

    prod of NK
  3. TNF-alpha
    TH1

    enhances inflam; increases vascular perm
  4. IL-3
    TH1, TH2

    stim hematopoeisis
  5. IL-4
    TH2

    B cell activation and growth, IgE isotype switch suppresses TH1/TH17 responses
  6. IL-5
    TH2

    B cell and eosinphil growth and differentiation
  7. IL-10
    TH2

    B cell differentiation; suppresses prod of TH1 cytokines
  8. TGF-beta
    TH2

    B cell differentiation; suppresses prod of TH1 cytokines
  9. IL-17
    TH17

    induce chemokines for neutrophil recruitment; induce IL-6; induce acute phase prot; syngergize w/ IFN-gamma, TNF-alpha
  10. IL-1
    prod by macrophages

    participates in initial stages of T cell growth; fever
  11. IL-6
    prod by macrophages and T cells

    participates in growth and differentiation of numerous leukocyte types; prom in induction of acute phase prot
  12. IL-12
    prod by dendritic cells, macrophages

    stimulates NK cells to prod IFN-gamma
  13. IL-23
    prod by dendritic cells

    stimulates TH17 cells to produce IL-17
  14. TNF-alpha
    prod by macrophages and NK cells

    enhances inflammation; increases vasc perm; cytotoxic factor
  15. GM-CSF
    prod by macrophages and T cells

    stimulates growth and differentiation of myeloid lineage

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