Pharm, E1/2, Antimicrobials

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Author:
HLW
ID:
97672
Filename:
Pharm, E1/2, Antimicrobials
Updated:
2011-08-20 14:05:12
Tags:
Pharm
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Pharm, E1/2, Antimicrobials
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  1. Broad Spectrum ABx (6):
    • Tetracyclines
    • Chloramphenicol & Derivs
    • Macrolides
    • Lincomycins
    • Fluoroquinolones
    • Sulfonamides
  2. Narrow Spectrum ABx (5):
    • B Lactams
    • Aminoglycosides
    • Polymyxin B
    • Colistin
    • Rifampin
  3. Bactericidal Drugs (6):
    • B Lactams
    • Polymyxin B
    • Colistin
    • Aminoglycosides
    • Fluoroquinolones
    • Metro
  4. Bacteriostatic Drugs (5):
    • Tetracyclines
    • Chloramphenicol & Derivs
    • Macrolides
    • Lincomycins
    • Sulfonamides
  5. Bactericidal Fx are dependent on...
    • Duration
    • Increasing Concentration
    • Post-Abx Effect
  6. Combination Therapy is useful in which cases (5)?
    • Mixed Infection
    • Synergistic Fx
    • Resistance
    • Avoid Toxicity
    • Bacterial Enzyme Inactivation
  7. 2x Bacteriostatic Drugs =>
    Additive
  8. 2x Bactericidal Drugs =>
    Synergistic
  9. Bactericidal + Bacteriostatic =>
    Antagonistic
  10. Resistance due to Antimicrobial Inactivation (via enzymes) has occurred with which drugs (3)?
    • Penicillins (G-, B lactamase)
    • Cephalosporins (G-, B lactamase)
    • Aminoglycosides
    • Chloramphenicol (G+/-)
  11. Resistance due to Alternation of Sensitive/Binding Site has occurred with which drugs (4):
    • Aminoglycosides
    • Erythromycin
    • Fluoroquinolones
    • Rifampicin
  12. Resistance due to Decreased Permeability has occurred with which drugs (1):
    Ampicillin
  13. Resistance due to decreased Drug Accumulation has occurred with which drugs (2):
    • Tetracyclines
    • Fluoroquinolones
  14. Resistance due to Alternate Metabolic Pathway has occurred with which drugs (2):
    • Trimethoprim
    • Sulphonamide

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