Pharm, E1/2, Antimicrobials

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HLW
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97674
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Pharm, E1/2, Antimicrobials
Updated:
2011-08-20 14:34:42
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Pharm
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Pharm, E1/2, Antimicrobials
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  1. What compound is used by bacteria to synthesize folic acid?
    Para-Aminobenzoic Acid (PABA)
  2. Sulfonamides inhibit which enzyme?
    Dihydropteroate Synthase
  3. Diaminopyrimidines inhibit wich enzyme?
    Dihydrofolate Reductase
  4. Sulfonamides and Diaminopyrimidines inhibit the production of which AA's?
    • Thymine
    • Purines
    • Methionine
    • Glycine
  5. Together, Sulfonamides and Diaminopyrimidines, act...
    Synergistically, Bactericidal
  6. Which drug group is a Weak Organic Acid, that is insoluble in water (Sulfonamides/Diaminopyrimidines)?
    Sulfonamides
  7. Which drug group is lipid soluble and widely distributed thrughout the body (Sulfonamides/Diaminopyrimidines)?
    Diaminopyrimidines
  8. Which drug accumulates in prostatic fluid and in milk?
    Diaminopyrimidines
  9. Diaminopyrimidines are metabolized by...
    The Liver
  10. Sulfonamides are metabolized by...
    The Liver (mostly)
  11. Sulfonamides are effective on:
    • G+
    • G-
    • Some protozoa, Coccidia
  12. Which Drug (Sulfonamides/Diaminopyrimidines), has metabolites that can cause renal damage?
    Sulfonamides
  13. Topical Sulfonamides include:
    • Silver Sulfadiazine
    • Mafenide
  14. Opthalmic Sulfonamides include:
    Sulfacetamide
  15. Which Drug, (Sulfonamides/Diaminopyrimidines), has a variation in plasma protein binding btw. 15%-90%?
    Sulfonamides
  16. Which drug, (Sulfonamides/Diaminopyrimidines), crosses the placenta and penetrates cerebral/synovial fluid?
    Sulfonamindes
  17. Long Acting Sulfonamides:
    • Sulfamethoxine
    • Sulfamethazine
    • Sulfathylphenazole
    • Sulfaethoxypyridazine
  18. Enteric Sulfonamides:
    • Succinylsulfathiazole
    • Sulfasalazine
    • Sulfaquinoxaline
    • Sulfaguanidine
    • Phthalylsulfathiazole
  19. Which sulfonamide is used to Tx colitis in dogs d/t to it's anti-inflammatory properties?
    Sulfasalazine
  20. What are the most commonly used Diaminopyrimidines?
    • Ormetoprim
    • Pyrimethamine
    • Trimethoprim
  21. Sulfonamides:Diaminopyrimidines are compounded at a ratio of __:__, and yield a plamsa ratio of __:__
    • 1:5
    • 1:20
  22. Sulfonamides/Diaminopyrimidines are effecive against
    • G+ (Strep, Staph Nocardia)
    • Some G- (Enterobacteria)
    • Some Protozoa (pneumocystis, coccidia & toxoplasma)
  23. Metabolization of Sulfonamides & Diaminopyrimidines
    • Sulfonamides => Acetylated & Conjugated with Glucaronic Acid
    • Diaminopyrimidines => Oxide & Hydroxylated Metabolites

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