Pharm, E1/2, Antimicrobials
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What compound is used by bacteria to synthesize folic acid?
Para-Aminobenzoic Acid (PABA)
Sulfonamides inhibit which enzyme?
Diaminopyrimidines inhibit wich enzyme?
Sulfonamides and Diaminopyrimidines inhibit the production of which AA's?
Together, Sulfonamides and Diaminopyrimidines, act...
Which drug group is a Weak Organic Acid, that is insoluble in water (Sulfonamides/Diaminopyrimidines)?
Which drug group is lipid soluble and widely distributed thrughout the body (Sulfonamides/Diaminopyrimidines)?
Which drug accumulates in prostatic fluid and in milk?
Diaminopyrimidines are metabolized by...
Sulfonamides are metabolized by...
The Liver (mostly)
Sulfonamides are effective on:
- Some protozoa, Coccidia
Which Drug (Sulfonamides/Diaminopyrimidines), has metabolites that can cause renal damage?
Topical Sulfonamides include:
- Silver Sulfadiazine
Opthalmic Sulfonamides include:
Which Drug, (Sulfonamides/Diaminopyrimidines), has a variation in plasma protein binding btw. 15%-90%?
Which drug, (Sulfonamides/Diaminopyrimidines), crosses the placenta and penetrates cerebral/synovial fluid?
Long Acting Sulfonamides:
Which sulfonamide is used to Tx colitis in dogs d/t to it's anti-inflammatory properties?
What are the most commonly used Diaminopyrimidines?
Sulfonamides:Diaminopyrimidines are compounded at a ratio of __:__, and yield a plamsa ratio of __:__
Sulfonamides/Diaminopyrimidines are effecive against
- G+ (Strep, Staph Nocardia)
- Some G- (Enterobacteria)
- Some Protozoa (pneumocystis, coccidia & toxoplasma)
Metabolization of Sulfonamides & Diaminopyrimidines
- Sulfonamides => Acetylated & Conjugated with Glucaronic Acid
- Diaminopyrimidines => Oxide & Hydroxylated Metabolites
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