Pharm, E1/3, B Lactam

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  1. B Lactams include:
    • Penicillin
    • Cephalosporins
    • Cephamycins
    • Carbapenems
    • Monobactams
  2. B Lactams interfere with... (Mechanism of Action)
    Transpeptidase Enzyme, responsible for Peptioglycan cross-links
  3. Suseptibility of B Lactams is dependent on:
    • B Lactamase
    • Permeability of Cell Well
    • Sensitivity of Pen Binding Protein
  4. Which Bacterial cell wall is NOT permeable to B-Lactam's?
  5. Bacteria can synthesize specific B-lactamases for which drugs?
    • Penicillinases
    • Cephalosporinases
  6. B Lactam Drugs are effective on bacteria that are characterized by...
    • Synthesis of Peptidoglycans
    • Grow Rapidly
  7. The physical and chemical properties of Pen are dependent on what molecular property?
    Acyl Side Chain
  8. Natural Pen's are effective against:
    • Strep
    • Staph
    • G+/- Bacilli
    • G+/G- Anaerobic
    • Spirochetes
  9. Natural Pen's are NOT effective against
    • Pseudomonas
    • Enterobacteria
    • Pen-ase producing Staph
  10. Classes of Semi-Synthetic Pens:
    • Isoxazolyl Pens
    • Aminopen's
    • Carboxypen's
  11. Opthalmic Isoxazolyl Pen
  12. *Which pen's are absorbed will when given PO
    • Isoxazolyl Pen (Cloxacillin, Oxacillin, Dicloxacillin, Nafcillin)
    • Natural (Pen V)
  13. PO Pens are suspended in ___, while those given IM/SQ are suspended in ___
    • PO= oil
    • IM/SQ= Aqueous
  14. Which Class of Pen is active against Pen-ase producing Staph?
  15. Which classes of Pen must be admin with B-lactamase inhibitors?
    • Natural
    • Aminopenicillins
    • Carboxypen
  16. Which semi-synthetic pens are broad spectrum?
    • Amoxi
    • Ampi
  17. Which class of Pen is most effective against B fragilis?
    Extended Spectrum
  18. B-Lactamase inhibiting additive drugs
    • Clavulanate
    • Sulbactam
  19. Which two Pen's have a low bioavailability in dogs, and are therefore admin with esters?
    • Ampicillin
    • Amoxicillin
  20. *Which Pen CANNOT be admin IV b/c it affects cardiac conduction?
    Procain Pen G
  21. *Other form of Pen G that is absorbed for 7 days:
    Benzathine Pen G
  22. *Pens mantain a high concentration in..
    • milk
    • (milk:plasma= 1:5)
  23. Pens are excreted as...(form)
    80% unchanged (metabolites => allergic Rxns)
  24. Where are most Pens exreted?
    • Glomerular Filtration
    • Proximal Tubule
  25. Which Pen is excreted by bile?
  26. What drug reduces the excretion of Pen via tubular secretion?
Card Set:
Pharm, E1/3, B Lactam
2011-08-21 01:03:28

Pharm, E1/3, B Lactam
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