Pharm, E1/3, B Lactam
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B Lactams include:
B Lactams interfere with... (Mechanism of Action)
Transpeptidase Enzyme, responsible for Peptioglycan cross-links
Suseptibility of B Lactams is dependent on:
- B Lactamase
- Permeability of Cell Well
- Sensitivity of Pen Binding Protein
Which Bacterial cell wall is NOT permeable to B-Lactam's?
Bacteria can synthesize specific B-lactamases for which drugs?
B Lactam Drugs are effective on bacteria that are characterized by...
- Synthesis of Peptidoglycans
- Grow Rapidly
The physical and chemical properties of Pen are dependent on what molecular property?
Acyl Side Chain
Natural Pen's are effective against:
- G+/- Bacilli
- G+/G- Anaerobic
Natural Pen's are NOT effective against
- Pen-ase producing Staph
Classes of Semi-Synthetic Pens:
- Isoxazolyl Pens
Opthalmic Isoxazolyl Pen
*Which pen's are absorbed will when given PO
- Isoxazolyl Pen (Cloxacillin, Oxacillin, Dicloxacillin, Nafcillin)
- Natural (Pen V)
PO Pens are suspended in ___, while those given IM/SQ are suspended in ___
Which Class of Pen is active against Pen-ase producing Staph?
Which classes of Pen must be admin with B-lactamase inhibitors?
Which semi-synthetic pens are broad spectrum?
Which class of Pen is most effective against B fragilis?
B-Lactamase inhibiting additive drugs
Which two Pen's have a low bioavailability in dogs, and are therefore admin with esters?
*Which Pen CANNOT be admin IV b/c it affects cardiac conduction?
Procain Pen G
*Other form of Pen G that is absorbed for 7 days:
Benzathine Pen G
*Pens mantain a high concentration in..
Pens are excreted as...(form)
80% unchanged (metabolites => allergic Rxns)
Where are most Pens exreted?
- Glomerular Filtration
- Proximal Tubule
Which Pen is excreted by bile?
What drug reduces the excretion of Pen via tubular secretion?
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