Pharm Week 9
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- beta blockers
- Beta 1: reduce calcium entry, reduce conduction velocity, automaticity, and recovery time. Decreases heart rate and contractility which decreases O2 demand.
- Beta 2: bronchoconstiction
- Angiotensin receptor II blockers (ARB's)
- Prevent the release of aldosterone (sodium retaining hormone)
- act on the renin-angiotensin-aldosterone system
- block angiotension II from the AT1 receptors
- cause vaso dilation and decrease periheral resistance
- do not cause cough
- Angiotensin-Converting Enzyme inhibitors (ACE)
- inhibit formation of angiotensin II (vasoconstrictor) and blocks release of aldosterone
- promotes sodium & water excretion, potassium retention
- cause little change in cardiac output or heart rate, but lower peripheral resistance
- treat hypertension, some heart failure
- cause caugh
- calcium channel blockers
- Block calcium in vascular smooth muscle =vasodilation
- Relaxation of coronary arteries which decreases vasospasms and increases O2 supply.
- Dilation of arterioles which decreases afterload and decreases O2 demand.
- anti-cholesterolinhibit the enzyme HMG CoA reductase
- inhibits the synthesis of cholesterol in the liver to decrease the concentration of cholesterol, decreases LDL, slightly increases HDL
- may see results with in two weeks, but are a lifetime drug
- antiviralsused to prevent or delay the spread of a viral infection
- inhibit viral replication by interfering with viral nucleic acid synthesis in the cell
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