Why do allosteric enz not display a hyperbolic curve?
display sigmoidal shape invece perche' the transition from inactive T state to active R state w/ increase in subst conc. Subst binding in one site will increase enz act of remaining sites....cooperativity
OR: sigmoidal curve is composite of two Michaelis-Menton curves; one for T state and one for R state; at low conc of subst, enz inactive form and resemble T state but as subst conc increase, enz goes to R state. Combining two curves gives an int which is sigmoidal