Can a drug's size affect drug dissolution? Why or why not? If yes, how do you accomplish this?
Yes, if the surface area of a drug relative to the amount of drug in the disintegrated drug particle is increased, then drug dissolution will increase. This happens by making the particle size of the disintegrated drug smaller/finer during the manufacturing process. The smaller drug particle size exposes a higher percent of drug molecules to GI fluid, thereby having a larger relative drug surface area.