Psychiatric - Schizophrenia Antipsychotics

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  1. What are the Characteristic symptoms of a schizophrenic?
    • Hallucinations
    • Delusions
    • Disorganized Speech
    • Grossly disorganized or catatonic behaviorNegative symptoms
  2. What drugs are used to treat schizophrenia?
    • 1st generation antipsychotics (FGAs or neuroleptics)
    • 2nd generation antipsychotics (SGAs or atypicals)
  3. Which FGAs (neuroleptics)are used to treat schizophrenia?
    • chlorpromazine (Thorazine)
    • thioridazine (Mellaril)
    • haloperidol (Haldol)
    • perphenazine (Trilafon)
    • fluphenazine (Prolixin)
  4. What are the advantages of FGAs (neuroleptics)?
    • cheap
    • effective for positive sx (perphenazine was 2nd best in CATIE trial)
  5. What are the disadvantages of FGAs (neuroleptics)?
    • MANY SE!
    • failure to change insight or judgment
    • lack of efficacy in 20-30% of pts
    • may worsen negative sx
    • DI with drugs that affect gastric pH
  6. What are the side effects of FGAs (neuroleptics)?
    • EPSE
    • prolactin elevation
    • sexual dysfx
    • anticholinergic effects
    • sedation
    • wt gain
    • dizziness
    • orthostatic hypotension
  7. Which SGAs (atypicals) are used to treat schizophrenia?
    • clozapine (Clozaril)
    • risperidone (Risperdal)
    • paliperidone (Invega)
    • olanzapine (Zyprexa)
    • quetiapine (Seroquel)
    • ziprasidone (Geodon)
    • aripiprazole (Abilify)
    • iloperidone (Fanapt)
    • asenapine (Saphris)
  8. How do most of the SGAs (atypicals) work?
    • serotonin-dopamine antagonism
    • (SDA more 5-HT2 than D2)
  9. What is the only drug succussfully used to treat pts refractory to FGAs?
    clozapine (Clozaril)
  10. Which SGAs are better than FGAs for depressive-type sx seen in schizophrenia?
    • aripiprazole (Abilify)
    • quetiapine (Seroquel)
Card Set:
Psychiatric - Schizophrenia Antipsychotics
2011-08-23 04:07:58
Psychiatric Schizophrenia Antipsychotics

Psychiatric - Schizophrenia Antipsychotics
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