Transition Drug Cards

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Transition Drug Cards
2011-09-30 21:12:38
Antiseizure Agents

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  1. Succinimides
    ethosuximide Zarontin
    • Seizure =excess energy/altered brain consciousness.
    • Tonic clonic-limbs move
    • Absense seizure-in a daze.
    • Control of absense seizures. May act in inhibitory neuronal systems, suppresses EEL Pattern associated with absense seizures.
    • Side effects-drowsiness, headache, blurred vision, pruritus, SJS, N/V/D
  2. Benzodiazepines-diazepam (Valium),
    • Management of anxiety disorders, acute alcohol withdrawl, muscle relaxant (rigid muscles with tonic clonix seizure).
    • Anadote-Flumazenel (Romazicon)-reverses sedation.
    • Subdues excess energy (sedation). Initial dose offers seizure control for 15-20 minutes after administration.
  3. Drugs for treatment of focal/partial seizures.
    Carbamazepine (Tegretol, Atretol)
    Treatment of refractory seizure disorders including partial seizures. Alters NA and CA channels directly/indirectly increasing acidity of GABA an inhibitory neurotransmitter thereby decreasing excessive acidity.
  4. Barbiturate/Barbituate like drugs.
    Phenobarbital (Solfoton, Luminal)
    • Long term treatment of tonic-clonic and cortical seizures.
    • General CNS depressant.
    • Subdues excess energy.
  5. Hydantoins
    Phenytoin (Dilantin)
    • Stabalizes neuronal membranes and prevents hyperexcitability caused by excessive stimulation.
    • Long term use-gingival hyperplasia-change in facial features.
    • Cardiac issures, alters bone marrow
    • Therapeutic level 10-20 mcg.
    • Prevents drug withdrawal seizures.
  6. Drugs that modulate the inhibitory neurotransmitter GABA
    valproic acid Depakene
    • Reduces abnormal electrical activity in the brain and may also increase GABA.
    • GABA inhibits overstimulation.
  7. Meds for tonic clonic seizures
    Benzodiazepam, phenobarbital, hydantoins
  8. Tonic clonic seizure that does not end
    • Status elipictus
    • Emergency
    • May learn to recognize aura
  9. Period just after seizure