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Angiotensin-Converting Enzyme Inhibitor
Captopril ("April for ACE inhibitor")
- Prevent conversion of Angiotensin 1 and Angiotensin 2.
- Hypotension, cough, loss of taste, tachycardia, hyperkalemia, angioedema.
- Monitor BUN, Creat and electrolytes. Monitor CBC for neutropenia and agranulocytosis. Alter effectiveness with allopurinol or NSAIDS. Should be on empty stomach. Call MD if angioedema.
- HTN-alone or with other treatments. CHF-alone or in combination with other treatments.
Angiotensin II Receptor Blockers
- Blocks Aldosterone effects of Angiotensin 2, thus causes vasodilation.
- URI (but no cough). Hyperkalemia. Impaired renal function. Monitor for respiratory infection. With or without meals is OK. Careful with drug interactions.
- HTN-alone or with other treatments. CHF
- HTN, CHF, slow progression of renal disease in pts. with HTN, Type 2 DM.
- Selectively blocks the bonding of angiotenon to specific tissue receptors found in the vascular smooth muscle and adrenal glands. Blocks the vasoconstriction and release of aldosterone.
Calcium Channel Blockers
- Inhibits the movement of CA ions across the membranes of cardiac and arterial muscle cells depressing the impulse and leading to slowed conduction decreased myocardial contractility and dilation of arterioles which lowers BP and decreases myocardial oxygen consumption.
- Dizziness, lightheadedness, headache, peripheral edema, bradycardia, atrioventricular block, flushing nausea.
- Treatment of essential HTN in the extended release form.
- Works on arterial smooth muscle to cause muscle relaxation leading to vasodilation and drop in blood pressure. Severe HTN. Maintains HTN during surgery.
- Tachycardia, hypotension, Flush, PLT aggregation, cyanide toxicity.
- For IV infusion only. Protect drug from light. Must use IV pump. Monitor BP Q5-15 min. Drug to drug interactions vary by drug.
- HYPERTENSIVE EMERGENCY.