Inamrinone (Inocor)-approved for use only on pt not responding to Dig, diuretics and vasodilators.
- Inhibit phosphodiesterase to produce + inotropic, thus vasodilates (increases CA+ thus stronger force of contraction, but can also increase O2 consumption and cause arrhythmias!!!
- Hypokalemia, hepatotoxicity with long term use, Thrombocytopenia.
- IV---dilute only in NS!! Monitor LFT, RFT, electrolytes and PLT count. Precipitates in IV line if given with Lasix. Must use separate IV line.
- Short term use in CHF if unresponsive to Dig, diuretics, and vasodilators.