Biopharm: Basic Concepts & Definitions
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What is biopharmaceutics?
the study of the physical and chemical properties
of a drug and its dosage form, including as related to the:
- onset of drug action
- duration of drug action
- intensity of drug action
What three main characteristics of drugs does biopharmaceutics deal with?
Biopharmaceutics deals with three main characteristics
- 1) physicochemical properties of drugs (e.g., weak acid, weak base, lipophilic, etc.)
- 2) drug formulation (e.g., extended release capsule, oral solution, suspension for IM injection, etc.)
- 3) route by which the drug is administered (e.g., oral, intravenous, rectal, etc.)
is the study of the relationship of these three characteristics with regard to drug delivery
Why is biopharmaceutics important?
will determine whether the drug is:
What is pharmacokinetics?
- Pharmacokinetics is concerned with four main parameters that control the fate of a drug following administration:
- 1) Absorption
- 2) Distribution
- 3) Metabolism
- 4) Excretion
These properties are also known as ADME
What is the difference between pharmacokinetics and pharmacodynamics?
Pharmacokinetics is how the body affects the drug
Pharacodynamics is how the drug affects the body (drug-receptor binding, occupancy-coupling pathways, etc.)
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