Lymphoma_Staging_and_Associations_2011.08.24.csv

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Most common translocation associated with NHL

Chromosomes 14 and 18
Most common translocation associated with mantle cell lymphoma

Chromosomes 11 and 14 - results in overexpression of cyclin D1
Translocation associated with high-grade small noncleaved lymphomas (Burkitt & non-Burkitt)

Chromosome 8 - involves c-myc dysregulation
Abnormalities associated with anaplastic large cell lymphoma

Chromosome 2 & 5 translocation (between NPM and ALK genes. CD30+ - allows for differentiation from carcinoma
Translocation associated with MALT lymphomas

Chromosomes 11 & 18. Often associated with H. pylori infection also
Lymphomas associated with Epstein-Barr

Burkitt lymphoma; Hodgkin disease; lymphomas in immunocompromised patients
Lymphomas associated with HTLV-1

Adult T-cell leukemia or lymphoma. Endemic in certain areas of Japan & the Caribbean
Lymphomas associated with HCV

Clonal B cell expansions & certain subtypes of NHL (especially in the setting of mixed cryoglobinuria)
Ann Arbor stage I

Involvement of a single lymph node region
Ann Arbor stage II

Involvement of 2+ lymph node regions on the same side of the diaphragm
Ann Arbor stage III

Involvement of lymph node regions on both sides of the diaphragem
Ann Arbor stage IV

Multifocal involvement of 1+ extralymphatic sites with or without associated lymph nodes or isolated extralymphatic organ involvement with distant nodal involvement
IPI for NHL

Negative prognostic indicators - APLES: Age>60; Performance status 2-4; LDH elevated; Stage (Ann Arbor) III-IV. 0-1 point = low risk; 2 = low intermediate; 3 = high intermediate; 4-5 = high

Author

elplute

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Card Set

Lymphoma_Staging_and_Associations_2011.08.24.csv

Description

Lymphomas

Updated

2011-08-25T17:19:38Z

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