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Most common translocation associated with NHL
Chromosomes 14 and 18
Most common translocation associated with mantle cell lymphoma
Chromosomes 11 and 14 - results in overexpression of cyclin D1
Translocation associated with high-grade small noncleaved lymphomas (Burkitt & non-Burkitt)
Chromosome 8 - involves c-myc dysregulation
Abnormalities associated with anaplastic large cell lymphoma
Chromosome 2 & 5 translocation (between NPM and ALK genes. CD30+ - allows for differentiation from carcinoma
Translocation associated with MALT lymphomas
Chromosomes 11 & 18. Often associated with H. pylori infection also
Lymphomas associated with Epstein-Barr
Burkitt lymphoma; Hodgkin disease; lymphomas in immunocompromised patients
Lymphomas associated with HTLV-1
Adult T-cell leukemia or lymphoma. Endemic in certain areas of Japan & the Caribbean
Lymphomas associated with HCV
Clonal B cell expansions & certain subtypes of NHL (especially in the setting of mixed cryoglobinuria)
Ann Arbor stage I
Involvement of a single lymph node region
Ann Arbor stage II
Involvement of 2+ lymph node regions on the same side of the diaphragm
Ann Arbor stage III
Involvement of lymph node regions on both sides of the diaphragem
Ann Arbor stage IV
Multifocal involvement of 1+ extralymphatic sites with or without associated lymph nodes or isolated extralymphatic organ involvement with distant nodal involvement
IPI for NHL
Negative prognostic indicators - APLES: Age>60; Performance status 2-4; LDH elevated; Stage (Ann Arbor) III-IV. 0-1 point = low risk; 2 = low intermediate; 3 = high intermediate; 4-5 = high