CYTOKINES

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Author:
azbenchaar
ID:
98440
Filename:
CYTOKINES
Updated:
2011-08-25 20:10:58
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CYTOKINES
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CYTOKINES
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  1. IL-1 local effects? (inflammation)
    • - Activates vascular endothelium
    • - Activates lymphocytes
    • - Local tissue destruction
    • - Increases access of effector cells
  2. IL-1 sytemic effects? (inflammation)
    • - Fever
    • - Production of IL-6
  3. TNF-𝛂 local effects? (inflammation)
    • - Activates vascular endothelium
    • - Increases vascular permeability (which leads to increased entry of IgG, complement, and cells to tissues)
  4. TNF-𝛂 systemic effects? (inflammation)
    • - Fever
    • - Mobilization of metabolites
    • - Shock
  5. IL-6 local effects? (inflammation)
    • - Lymphocyte activation
    • - Increased antibody production
  6. IL-6 systemic effects? (inflammation)
    • - Fever
    • - Induces acute phase protein production by hepatocytes
  7. IL-8 local effects? (inflammation)
    - Chemotactic factor, recruits neutrophils, basophils, and T cells to site of infection
  8. IL-12 local effects? (inflammation)
    • - Activates NK cells
    • - Induces the differentiation of CD4 T cells into TH1 cells

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