Lipid metabolism 2
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Where are fatty acids broken down?
Where are fatty acids synthesized
In the cytosol
How do you get acetyl co A out of the mitochondria for fatty acid synthesis?
Reach with OAA to form citrate, which can get into the cytosol through a translocase
What does citrate lyase do?
Breaks citrate into OAA + acetyl coA. Uses ATP
How is OAA transported back into mitochondria?
Converted to malate (via malate dehydrogenase) or converted to pyruvate (malate dehydrogenase and malic enzyme)
How can OAA produce 1 NADPH in the cytosol?
By being coverted to malate (loses reducing equivelent) and then being converted to pyruvate which uses oxidative decarboxylase to produce pyruvate.
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