Antiarrhythmics

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Author:
Kate718
ID:
98904
Filename:
Antiarrhythmics
Updated:
2011-08-29 16:13:16
Tags:
Pharmacology
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Description:
Chapter 17
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  1. Sinus Rhythm
    • Normal heart rate
    • Normal conduction of current
  2. Ectopic Beat
    Heart response to impulses generated from somewhere not the SA node
  3. AV Re-entry
    • Current forced back through the AV node multiple times
    • Causes extra heart beats, always forms next to AV node
    • 75% of cases occur in women
  4. Wolf-Parkinson-White Syndrome
    Pre-excitation of ventricles due to extra pathway called Bundle of Kent
  5. Causes of Dysrhythmias
    • Abnormal generation (not by SA node)
    • Abnormal impulse conduction
  6. Phase 0
    Rapid depolarization- influx of Na
  7. Phase 1
    Breif period of rapid repolarization when Na channels close and K open
  8. Phase 2
    • Plateu phase
    • Ca Channels open inward and trade off with K, maintained depolarized state
  9. Phase 3
    Inward Ca channels close and K remains open causing rapid repolarization
  10. Phase 4
    Resting membrane potential and distolic depolarization
  11. Refraxtory period
    Time when atria and ventricles are at rest and cannot be stimulated
  12. Class 1A
    • Block ass/dissociation w/ Na channels
    • Intermediate rate od ass/dis
    • Increase refractory period and Q-T interval
    • Used for atrial/ventricular tacky arrythmias
  13. 1A Drugs
    • Quinidine
    • Procainamide
    • Disopyramide
    • "Double Quarter Pounder"
  14. Class 1B
    • Have fat ass/dis w/ Na channels
    • Depresses phase 0 slightly
    • Used for acute ventricle arrythmias
    • Choice for emergency ventricle arr
  15. 1B Drugs
    • Lidocaine
    • Pitenytoin
    • Mexicitine
    • Tocainide
    • "Lettuce Tomato Mayo Pickles"
  16. Class 1C
    • Slow ass/dis with Na channels
    • Marked depression of phase 0 Na influx
    • Profound slowing of conduction
  17. 1C Drugs
    • Morcizine
    • Propanenone
    • Flecanide
    • "More Fries Please"
  18. Class 2
    • Beta Blockers
    • Slow phase 4, distolic depol and depress autometicity (HR)
  19. Class 2 Drugs
    • Atenolol
    • Esmolol
    • Propanolol
    • Metoprolol
  20. Class 3
    • K channel blockers to prolong repolarization
    • Phase 3-rapid repol
    • Phase 2
    • Prolongs duration of action potential with affecting phase 0
  21. Class 3 Drugs
    • Amiodarone
    • Sotolol
    • Dofetilide
  22. Class 4
    • Ca channel blockers
    • Prolongs phase 2 of action potential
  23. Class 4 Drugs
    • Verapamil
    • Diltiazem
  24. Multaq
    Doesn't fit into any classification
  25. Cardiac Ablation
    Surgery used when medicinal therapy has failed

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