Blood Drugs

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Blood Drugs
2011-08-29 19:10:36

Chapter 20
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  1. Thrombosis
    • Formation of an unwanted clott inside a blood vessel
    • Can lead to heart attack, stroke, pulmonary ambolism, deep vein thrombosis
  2. Bleeding Disorders
    • Uncontrolled bleeding
    • Usually genetic
  3. Anemia
    Low RBC count, normal is 40-45%
  4. TXA2
    • Stimulates activation of other platelets
    • Facilitates platelet aggulation
    • Causes local vasoconstriction
  5. Iron Products
    • Treatment for anemia
    • Ferrous Sulfate
  6. Folic Acid
    • Treatment for Anemia
    • Required for maintance and synthesis of RBC
    • Results in large, immature and dysfunctional RBCs
  7. Cyanocobalamin Deficiency (B12)
    • Indicates for pennicious anemia- lack of B12
    • Treatment is B12 injections for life
  8. Erythropoetin
    • Normally made in the kidney
    • Epoetin Alpha and Darbepoetin are synthetic erythropoetins
    • Indicated- anemias associated with renal failure
  9. Dipyridamole (Perantine)
    • Platelet anhesion inhibitor
    • MOA- increases TXA2, increases prosttacycin
    • Agonist, MOA is unclear
    • Used in combinaion with Coumadin to prevent thrombin formation on prostetic heart valve as it has no endotheleium
  10. Ticlopidine HCL and Clopidogrel (Plavix)
    inhibit activation of platelets
  11. Abcixmab
    • MOA- blocks the binding of Von Willibrand factor to receptor sites on platelets
    • Given with heprin during surgical procedures to prevent platelet agregation
  12. Asprin
    • MOA- inhibits TXA2 by the arachadonic acid pathway
    • Prevents heart attack
  13. Heparin
    • Naturally occuring molecule in the body produced by basophil and mast cells
    • Injectable anticoagulant
    • Interferes with formation of fibrin/fibrinogen
    • Has effect on Anti-Thrombin III
    • Can cause Heparin Induced Thrombocytopenia (HIT)
    • Used in deep vein thrombosis, Pulmonary embalisn, and surgical procedures
  14. Low Moelcular Weight Heparin (LMWH)
    • Increase ratio of anti-factor 10to anti-factor 2 activity
    • Less effect on thrombin
    • Used for deep vein thrombosis and pulmonary
    • Long acting (24hrs)
  15. Direct Thrombin Antagonist
    • Leperudin and Agatroban
    • Prevent fibrin blood clotts
    • indicated by direct thrombin disorders where heparin is too much
  16. Vitamin K Antagonist
    • Warfarin
    • MOA_ Inhibits synthesis of clotting factors 2,7,9,10 in the liver
    • Prevents DVT and Pulmonary
  17. Thrombolytic Drugs
    • Drugs used to dissolve blood clotts
    • MOA- Activate conversaion plasminogen to plasmin which dissolves clotts
  18. Alteplase (Activase)
    • MOA- Rapidly activates plasminogen that has bound to fibrin in clott
    • Used in heart attack, pulmonary, and acute aschemic stroke
  19. Streptokinase (Streptase)
    • MOA- Rapidly activates plasminogen that has bound to fibrin in clott
    • Used in heart attack, pulmonary, and acute aschemic stroke
  20. Aminocaproic Acid (Amicar)
    • MOA- Inhibites fibrinolysis by inhibiting conversion of plasminogen to plasmin
    • Used in hemophilia and post surgery
  21. Protamine Sulfate
    • Reverses effects of heparin
    • Basic and combines with acidic heparin to form neutral salt
    • Used post-surgery and to reverse heparin
  22. Vitamin K
    Promotes Factors 2,7,9, and 10
  23. Aprotinin (Trasylol)
    • Blocks plasmin
    • Indicated by blood loss in surgery and post-operative bleeding
  24. Tranexamic (Cyclokapron)
    • Inhibits plasmin
    • Used in post-operative bleeding