Antianginal and Antihypertensive Drugs

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Nitroglycerine
- Taken under the tongue to avoid 1st pass effect
- Relieves tightness in chest
- Causes dilitation of smooth muscle
Steps for Vascular smooth muscle constriction

Increase Nitrates>Nitrites>Nitric oxide>GMP>Myosin light chain
Treatment of Hypertension
- Block renin/angiotensin system
- Increase sympathetic tone>Beta blockers reversed
Thiazide
- Diuretic used to lower BP
- Removes Na from arteries and as a result lowers blood volume
- Preferred drug to treat hypertension
Beta-Adrenoceptor Blockers
- Block B receptor
- Decreases Renin production
ACE
- Breaks down bradykinin
- Bradykinin causes dry cough as a side effect

Author:	Anonymous
ID:	98967
Card Set:	Antianginal and Antihypertensive Drugs
Updated:	2011-08-30 03:18:17
Tags:	Pharmacology
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Description:	Chapter 19
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