Card Set Information

2011-08-30 13:19:01

Activity 1-50
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  1. Refers to the relative amount of drug that reaches the systemic circulation
  2. A measure of acidity
  3. The ratio of drug concentration in 2 phases separated by a semipermeable membrane
    Concentration Gradient
  4. Refers to a more comprehensive concept that includes the drug formulation and the dynamic interactions among the drug, its formulation matrix, its container, and the patient
    DDS or Drug Delivery System
  5. Substance that may exist in more than one crystalline form or amorphous form
  6. These are addition compounds of drug and water
  7. The equation that best describe the overall rate of drug dissolution
    Noyes-Whitney Equation
  8. Which type of formulation may accidentally release active drug from a dosage form
    Vehivle substances
  9. Ability of chemical compound to exist as optically active sterioisomers or enantiomers
  10. The dissociation constant for weak base which ionizes according to the equation: HB + H2O = H2O + B is equal to ______
    Kb = [H3O] + [B] / [BH]
  11. Drugs administered by intrathecal route are absorbed in the ____
    • CSF or Cerebrospinal Fluid
    • Spinal Fluid
  12. Is the delivery of the active ingredient from a dosage form into a solution
  13. The process by which a drug enters the bloodstream
  14. Those multiple source drug products that contain identical amount of the identical active ingredients in identical dosage form are called ____
    Pharmaceutical Equivalent
  15. Are additives which are necessary in formulating a dosage form from a drug
    Pharmaceutical Excipient
  16. The dose size required to maintain the effectiveness or therapeutic concentration according to the dosage regimen
    Steady State?
  17. The ratio of drug concentration in the lipid phase over the concentration of the drug in the aqueous phase
    APC or Apparent Partition Coefficient (Lipid-Water Coefficient)
  18. The route of administration that gives the fastest onset of pharmacologic effect is ____
    IV bolus administration
  19. The rapid degradation of a drug by liver enzymes in a liver prior to its absorption
    First pass effect?
  20. The mathematical equation used in determining the passage of drug across cell membrane
    Henderson Hasselbach Equation
  21. These are addition compounds of drug and organic solvents
  22. The extent or fraction of drug absorbed upon extravascular administration in comparison to the standard with similar dose size administered
  23. Pharmacokinetic parameter that gives useful information about the amount of drug systemically absorbed is ____
    AUC or Area Under the Curve
  24. The route of drug administration that provides complete (100%) bioavailability is ____
    Intravascular Route
  25. The extent of ionization of a weak electrolyte drug is dependent on ____ and ____
    pKa and pH
  26. The process with the slowest rate constant in a system of simultaneous kinetic process
    Rate Limiting Step
  27. The lipid phases employed in the determination of apparent partition coefficient include ____
    • Octanol
    • Chloroform
    • Cyclohexane
    • Isopropyl Myristate
  28. The ions of added electrolyte require water for hydration reducing the amount of water available for the solution of the non-electrolyte is the phenomenon of ____
  29. An agent that takes up another substance into its intraspace structure is called ____
  30. The property of absorbing moisture from the atmosphere
  31. Method that includes sampling of blood, spinal fluid, tissue biopsy, or any biological material that requires parenteral or surgical intervention in the patient is ____
    Invasive Method
  32. The prerequisite of absorption at the absorption site is ____
    solution or receptor?

  33. Which of the following peroral dosage forms is likely to exhibit the shortest lag time
    powders or solutions(true solutions)?
  34. The rectal route of administration may be preferred over the peroral route for some systemic-acting drugs because
    Partial first-pass effect
  35. Differences in bioavailability are most frequently observe with drugs administered by which of the ff routes?
    Oral and Rectal?
  36. Which of the following series in kinetic processes may be the rate-limiting step for drugs that are poorly soluble in aqueous media
    Drug Dissolution
  37. Use of free acid or free base form of the drug ____ the rate of drug dissolution from a tablet (increases, decreases)
  38. Which of the following is the first process that must occur before a drug can become available for GI absorption from a tablet dosage form?
    Formation of solutions?
  39. Which of the ff types of dosage form does not require dissolution prior to absorption?
    Intravenous Dosage Form
  40. Given the pKa value of a drug, the theoretical equilibium ratio of weak acids can be calculated as
    Ra = 1 + antilog (pHx - pKa) / 1 + antilog (pKa - pHp)
  41. APC can be calculated using the following formula
    APC = (Co2 - C'2) * a / C'2 * b
  42. Are complexes that typically involve a ring-like structure formed by the interaction between a partial ring of atoms and a metal
  43. Equal mixtures of dextrorotatory and levorotatory enantiomers are called
    Racemic Mixtures
  44. Different polymorphs of the same drug exhibit differences in ____
    Physical Properties
  45. Using the equation dc/dt = DA / h * (Cs-C), which factor/s is/are inversely proportional to the rate of dissolution in tle lipid membrane of lipoid soluble unionize substances?
    h or Thickness of the standard layer
  46. The smallest particle size approved by the FDA is ____
    1 - 10 micrometer
  47. What factors may influence drug liberation process?
    • Route of Administration
    • Physico-chemical Factors
    • Pharmaco-technical Factors
  48. Substances that exist as ions and rapidly dissociates in water are called ____
  49. Aqueous phase employed in the determination of APC ____
    H2O or Water?
  50. What are the characteristic of weak electrolytes?
    molecular form and ionized form