MCTD

Card Set Information

Author:
Mat
ID:
99073
Filename:
MCTD
Updated:
2011-08-30 18:43:27
Tags:
Rheum2
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Description:
MCTD
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  1. What is Mixed Connective Tissue Disease?
    characterized by features of systemic sclerosis, myositis, and systemic lupus erythematosus accompanied by antiribonucleoprotein antibody positivity.
  2. How does MCTD typically manifest?
    Mixed connective tissue disease typically manifests with arthralgia or arthritis, Raynaud phenomenon, serositis, and an inflammatory muscle disease.
  3. What is the treatment of MCTD?
    Treatment in patients with MCTD involves managing the individual disease manifestations. Corticosteroids and other immunosuppressive agents are used in patients with myositis, whereas NSAIDs, antimalarial agents, or more potent agents such as azathioprine, methotrexate, or mycophenolate mofetil are indicated for those with arthritis. Vasodilatory agents are beneficial in patients with pulmonary arterial hypertension, and angiotensin-converting enzyme inhibitors help to treat renovascular disease.
  4. How is MCTD diagnosed?
    Diagnosis generally requires high titers of antiribonucleoprotein antibodies accompanied by three of the following features: Raynaud phenomenon, synovitis, swollen hands, and myositis.

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