HTN Drugs

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Author:
swusops
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99655
Filename:
HTN Drugs
Updated:
2011-09-04 08:23:37
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Description:
HTN info first exam
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  1. Thiazide Diuretics - Mechanism
    Inhibits Sodium Chloride Transporter in the distal
  2. Thiazide Diuretics - Adverse Effects
    AE: electrolyte disturbance, orthostatis, dizziness
  3. Thiazide Diuretics - Monitor
    Monitor: BUN/SCr, electroltyes
  4. Thiazide Diuretics - Drugs
    HCTZ (12.5-25), Chlorthalidone (12.5-25), Metolazone (Zaroxolyn, 2.5-5)
  5. Loop Diuretics - Drugs
    Bumetanide (Bumex 0.5-2), Furosemide (Lasix 20-80), Toresmide (Demadex 2.5-10)
  6. Loop Diuretics - Mechanism
    Inhibits sodium/potassium/chloride transporter in ascending loop of henle. note - not used for HTN alone
  7. Loop Diuretics - Adverse Effects
    electrolyte disturbance, orthostasis, dizziness
  8. Loop Diuretics - Monitor
    BUN/SCr, electrolytes, serum
  9. Aldosterone Antagonists - Drugs
    Spironolactone (Aldactone 50-100), Eplerenone (Inspra 25-50)
  10. Aldosterone Antagonists - Mechanism
    Potassium sparing, antagoizes aldosterone receptor in DCT
  11. Aldosterone Antagonists - Adverse Effects
    hyperkalemia, GI, gynecomastia (eplerenone causes less because of epoxide group)
  12. Aldosterone Antagonists - Monitor
    BUN/SCr, electrolytes
  13. Selective Beta Blockers - Drugs
    Atenolol (Tenormin 25-100), Bisprolol (Zebeta 2.5-10), Metoprolol (Lopressor 50-100), Metoprolol XR (Toprol XL 50-100), Nebivolol (Bystolic 2.5-40)
  14. Selective Beta Blockers - Mechanism
    Selectively antagonizes the beta 1 adrenoreceptor
  15. Selective Beta Blockers - Adverse effects
    heart failure, heart block, depression, bradycardia, dyspnea, dizziness, fatigue
  16. Selective Beta Blockers - Monitor
    BUN/SCr, HR
  17. Alpha/Beta-Blockers - Drugs
    Carvedilol (Coreg 12.5-50), Labetalol (Trandate 200-800)
  18. Alpha/Beta-Blockers - Mechanism
    Antagonizes alpha 1 and beta 1
  19. Alpha/Beta-Blockers - Adverse effects
    heart failure, heart block, depression, bradycardia, dyspnea, dizziness, fatigue
  20. Alpha/Beta-Blockers - Monitor
    BUN/SCr, HR
  21. Angiotensin Converting Enzyme ACE Inhibitors - Drugs
    Benazepril (Lotension 10-40), Captopril (Capoten 25-100), Enalapril (Vasotec 2.5-40), Fosinopril (Monopril 10-40), Lisinopril (Prinivil, Zestril 10-40), Moexipril (Univasc 7.5-30), Perindopril (Aceon 4-8), Quinapril (Accupril 10-40), Ramipril (Altace 2.5-20), Trandolapril (Mavik 1-4)
  22. Angiotensin Converting Enzyme ACE Inhibitors - Mechanism
    Inhibits the conversion of angiotensin I to angiotensin II
  23. Angiotensin Converting Enzyme ACE Inhibitors - Adverse Effects
    Angiodema, hyperkalemia, cough, hypotension, renal impairment
  24. Angiotensin Converting Enzyme ACE Inhibitors - Monitor
    BUN, SCr, electrolytes
  25. Angiotensin II Receptor Blockers ARB - Drugs
    Azilisartan (Edarbi 40-80), Candesartan (Atacand 8-32), Eprosartan (Teveten 400-800), Irbesartan (Avapro 150-300), Losartan (Cozaar 25-100), Olmesartan (Benicar 20-40), Telmisartan (Micardis 20-80), Valsartan (Diovan 80-320)
  26. Angiotensin II Receptor Blockers ARB - Mechanism
    Antagonizes the angiotensin II AT1 receptor
  27. Angiotensin II Receptor Blockers ARB - Adverse Effects
    angioedema, hyperkalemia, hypotension, renal impairment
  28. Angiotensin II Receptor Blockers ARB - Monitor
    BUN/SCr, electrolytes
  29. Calcium Channel Blockers - Non Dihydropyridines - Drugs
    Dilitazem E, ER (Cardizem CD 180-420, LA 120-540), Verapamil IR, LA (Calan/Isoptin 80-320, SR 120-360), Verapamil Coer (CoveraHS/Verelan PM 120-360)
  30. Calcium Channel Blockers - Non Dihydropyridines - Mechanism
    inhibits calcium ion influx into vascular smooth muscle and myocardium, decr SVR, dilates coronary artery, prolongs AV node refractory period
  31. Calcium Channel Blockers - Non Dihydropyridines - Adverse Effects
    bradycardia, AV block, arrhythmia, hypotension, heart failure, edema, constipation
  32. Calcium Channel Blockers - Non Dihydropyridines - Monitor
    BUN/SCr, LFTs, HR. Note more likely to have a depressant effect on heart
  33. Calcium Channel Blockers - Dihydropyridines - Adverse Effects
    angina, edema, fatigue, dizziness
  34. Calcium Channel Blockers - Dihydropyridines - Mechanism
    Inhibits calcium ion influx into vascular smooth muscle and myocardium
  35. Calcium Channel Blockers - Dihydropyridines - Drugs
    Amlodipine (Norvasc 2.5-10), Felodipine (Plendil 2.5-20), Isradipine (Dynacirc SR 2.5-10), Nicardipine SR (Cardene SR 60-120), Nifedipine LA (Adalat CC/Procardia XL 30-60), Nisoldipine (Sular 10-40)
  36. Central Acting - Drugs
    Clonidine/patch (Catapres/TTS 0.1-0.8/0.1-0.3), Methyldopa (Pregnancy, Aldomet 250-1000)
  37. Central Acting -Mechanism
    stimulates alpha 2 adrenoreceptors
  38. Central Acting - Adverse Effects
    orthostasis, bradycardia, sedation, constipation, rebound HTN
  39. Central Acting - Monitor
    BUN/SCr, HR
  40. Direct Vasodilators - Monitor
    BUN/SCr, CBC, ANA
  41. Direct Vasodilators - Adverse Effects
    HA, GI, tachycardia
  42. Direct Vasodilators - Mechanism
    directly dilates peripheral vessels
  43. Direct Vasodilators - Drugs
    Hydralazine (Apresoline 25-100: used more commonly in heart failure and HTN Crisis), Minoxidil (more potent, stim hair growth)
  44. Direct Renin Inhibitors - Monitor
    BUN/SCr, electrolytes
  45. Direct Renin Inhibitors - Adverse Effects
    angioedema, hypotension, hyperkalemia, GERD, renal impairment
  46. Direct Renin Inhibitors - Mechanism
    decreases plasma renin activity, inhibits conversion of angiotensinogen to angiotensin I
  47. Direct Renin Inhibitors - Drugs
    Aliskerin (Tekturna 150-300)

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