a. Calcium Channel Blocker (CCB). Used to treat HTN, angina and arrhythmias. Can be used to treat chronic stable, unstable, and Prinzmetal’s (variant) angina.
b. They reduce Ca2+ entry into the cells so vascular smooth muscle relaxes (vasodilation), decreases myocardial force generation and decreased HR. They lower BP by decreasing peripheral vascular resistance.
- c. Anti-anginal effects of CCBs are derived both
- from their vasodilator and cardiodepressant actions. Vasodilation = increase in O2 supply.
d. Diltiazem is an intermediate between verapamil and the dihydrophyridines in its selectivity for vascular calcium channels. It’s able to relieve coronary vasospasm by dilating coronary arteries and is particularly useful in relieving the symptoms of variant angina.